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| Changes and role of serum glutamate levels and Na+-K+-ATPase activities in newborns with hyperbilirubinaemia |
| YANG Fuzhi,LI Weisheng,SU Gexin,ZHANG Qian,CHEN Xiaoling,and LIU Hongling |
| Department of Pediatrics,Guangdong Provincial Corps Hospital,Chinese People’s Armed Police Forces,Guangzhou 510507,China |
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Abstract Objective To study the changes and clinical significance of serum glutamate concentrations and Na+-K+-ATPase activities in newborns with hyperbilirubinaemia. Methods Ninety-one newborns with hyperbilirubinaemia in varying severity and 32 controls were recruited in this study; their serum glutamate concentrations and Na+-K+-ATPase activities were detected using Beckman amino acid analyzer and colorimetry. At one time,they received hearing test and later interview. Results Serum glutamate concentrations and Na+-K+-ATPase activities were (61.34±11.40) μmol/L and (0.212±0.026) μmolPi/（mg·h）, respectively, in newborns with hyperbilirubinaemia, significautly different from those in controls（P<0.01）,and the changes of them were closely related to total bilirubin level. The incidence of hearing disorder also increased in high bilirubin neonates.Conclusions High glutamate level and low Na+-K+-ATPase activities in newborns with hyperbilirubinaemia are possibly closely related to toxicity of bilirubin, the changes of them are likely to predict early the risk of brain disease in newborns with hyperbilirubinaemia.
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Received: 16 March 2012
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2013, Vol. 24 
