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| Clinical early warning value of plasma homocysteine assay in elderly stroke patients |
| JIN Yijun and LU Jianhong. |
| Department of Clinical Laboratory, Zhejiang Provincial Corps Hospital, Chinese People’s Armed Forces, Jiaxing 314000, China |
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Abstract Objective To investigate the value of plasma homocysteine (HCY) levels determination in early warning of elderly stroke disease. Methods 143 elderly stroke patients were admitted from January 2010 to July 2012. The subjects were divided into cerebral infarction and intracerebral hemorrhage groups. 371 elderly healthy subjects were recruited as the control group. Fasting venous blood samples were collected, and HCY levels were determined by enzyme chemical method. Results In both cerebral infarction and cerebral hemorrhage group of patients, plasma HCY level was significantly higher than that in the control healthy group, with significant difference (P<0.05). HCY level in cerebral infarction and intracerebral hemorrhage groups, however, showed no statistically significant difference (P>0.05). Conclusions HCY levels in aged patients with acute cerebral infarction and cerebral hemorrhage are closely linked; examination of HCY levels in aged patients may have a warning value on stroke. However, HCY level cannot distinguish cerebral infarction and cerebral hemorrhage in the clinical diagnosis.
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Received: 27 August 2012
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庄爱霞, 姜建东, 刘 娟, 等.叶酸维生素B12治疗高同型半胱氨酸血症对颈动脉粥样硬化的影响［J］.脑与神经疾病杂志, 2011, 19（3）: 210-212.［2］ 冯桂贞, 林安基, 吴仕福, 等.急性脑梗死中医辨证分型与同型半胱氨酸、超敏C反应蛋白水平的相关研究［J］.光明中医, 2009, 24（8）: 1419-1420.［3］ 袁平宗, 李传达, 汤雪彪.血浆同型半胱氨酸测定对老年冠心病的临床价值［J］.国际检验医学杂志, 2012, 33（3）: 303-304.［4］ 陈春暖, 黄金莎, 王 涛.脑血管疾病患者血浆中同型半胱氨酸的丰度及相关性研究［J］.卒中与神经疾病, 2011, 18（1）: 13-16.［5］ 何海明, 祝 峰, 施根林, 等.食管癌患者手术后血浆HCY和血清FA、维生素B12含量检测及其临床意义［J］.武警医学, 2010, 21（6）: 481-482.［6］ 马如华, 卢星文, 闫晓英.血浆同型半胱氨酸升高与脑梗死患者颈动脉硬化的关系［J］.实用医学杂志, 2012, 28（4）: 600-602.［7］ 胡晓芳, 安殿梅, 袁 笑, 等.脑血管病患者高HCY血症与叶酸和维生素B12的相关性研究［J］.中国实验诊断学, 2012, 16（5）: 807-809.
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| ［1］ |
庄爱霞, 姜建东, 刘 娟, 等.叶酸维生素B12治疗高同型半胱氨酸血症对颈动脉粥样硬化的影响［J］.脑与神经疾病杂志, 2011, 19（3）: 210-212.［2］ 冯桂贞, 林安基, 吴仕福, 等.急性脑梗死中医辨证分型与同型半胱氨酸、超敏C反应蛋白水平的相关研究［J］.光明中医, 2009, 24（8）: 1419-1420.［3］ 袁平宗, 李传达, 汤雪彪.血浆同型半胱氨酸测定对老年冠心病的临床价值［J］.国际检验医学杂志, 2012, 33（3）: 303-304.［4］ 陈春暖, 黄金莎, 王 涛.脑血管疾病患者血浆中同型半胱氨酸的丰度及相关性研究［J］.卒中与神经疾病, 2011, 18（1）: 13-16.［5］ 何海明, 祝 峰, 施根林, 等.食管癌患者手术后血浆HCY和血清FA、维生素B12含量检测及其临床意义［J］.武警医学, 2010, 21（6）: 481-482.［6］ 马如华, 卢星文, 闫晓英.血浆同型半胱氨酸升高与脑梗死患者颈动脉硬化的关系［J］.实用医学杂志, 2012, 28（4）: 600-602.［7］ 胡晓芳, 安殿梅, 袁 笑, 等.脑血管病患者高HCY血症与叶酸和维生素B12的相关性研究［J］.中国实验诊断学, 2012, 16（5）: 807-809.
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2013, Vol. 24 
