小凹蛋白-1在乳腺癌组织中的表达及其与乳腺癌浸润转移的关系

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Abstract Objective To investigate the correlation between caveolin-1 expression and clinicopathological factors and prognosis in patients with human breast carcinoma. Methods Using immunnohistochemistry to analyze the caveolin-1 expression in 168 patients with human breast carcinoma and adjacent normal breast tissue. The relationship of caveolin-1 expression and clinicopathological factors were analyzed using statistical software Prism 5.0. Results The expression of caveolin-1 in breast carcinoma was significantly lower than that in adjacent normal tissues (P＜0.01).The caveolin-1 expression was significantly correlated with advancing clinical stage(P=0.044),presence of maxillary lymph node matastasis(P=0.039),and the increase of HER-2 positive(P=0.014). The difference between groups was statistically significant (P＜0.01).The patients with breast carcinoma and positive expression of caveolin-1 had a higher five-year survival rate(P=0.018). The expression of caveolin-1 was not correlated with tumor size,age of the patients and histological grade. Conclusions The expression of caveolin-1 may be involved in the occurrence and development process of breast carcinoma.The expression of caveolin-1 has a certain relationship with clinicopathological factors in breast carcinoma. It may play a role of tumor inhibiting factor in breast carcinoma progression.

Key words： breast carcinoma caveolin-1 pathology immunohistochemistry

Received: 07 December 2012

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	Articles by authors
	YANG Guang
	GAO Wanfeng
	YE Shengquan
	and ZENG Xianyang

Cite this article:

YANG Guang,GAO Wanfeng,YE Shengquan等. Expression of caveolin-1 in breast carcinoma and its correlation with infiltration and metastasis of breast carcinoma[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2013, 24(5): 379-382.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2013/V24/I5/379

[1]	Li T,Sotgia F,Vuolo M A, et al. Caveolin-1 mutations in human breast cancer:functional association with estrogen receptor alpha positive status[J].Am J Pathol,2006,168(1):1998-2013.
[1]	Li T,Sotgia F,Vuolo M A, et al. Caveolin-1 mutations in human breast cancer:functional association with estrogen receptor alpha positive status[J].Am J Pathol,2006,168(1):1998-2013.
[2]	回允中(译). 阿克曼外科病理学[M]. 北京:人民卫生出版社,2009:1603-1615.
[2]	回允中(译). 阿克曼外科病理学[M]. 北京:人民卫生出版社,2009:1603-1615.
[3]	National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology:breast screening and diagnosis,version.1.2010[M]. Washington:National Comprehensive Cancer Network, Inc, 2009: 3.
[4]	Wiechen K, Diatchenko L, Agoulnik A, et al. Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene[J]. Am J Pathol, 2001,159(5):1635-1643.
[3]	National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology:breast screening and diagnosis,version.1.2010[M]. Washington:National Comprehensive Cancer Network, Inc, 2009: 3.
[5]	Vihanto M M,Vindisl C,Djonov V,et al. Caveolin-1 is required for signaling and membrane targeting of EphB1 receptor tyrosine kinase[J].J Cell Sci,2006,119(17):2299-2309.
[4]	Wiechen K, Diatchenko L, Agoulnik A, et al. Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene[J]. Am J Pathol, 2001,159(5):1635-1643.
[6]	Cantiani L,Manara M C,Zucchini C,et al.Caveolin-1 Reduces Osteosarcoma Metastases by Inhibiting c-Src Activity and Met Signaling[J].Cancer Res,2007,67(16):7675-7685.
[7]	Williams T M,Cheung M W,Park D S,et al.Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice[J].Mol Bool Cell,2003,14(3):1027-1042.
[5]	Vihanto M M,Vindisl C,Djonov V,et al. Caveolin-1 is required for signaling and membrane targeting of EphB1 receptor tyrosine kinase[J].J Cell Sci,2006,119(17):2299-2309.
[8]	高万峰,杨光,史昌乾,等.小凹蛋白-1在食管鳞癌中的表达及意义[J].武警医学,2011,22(10):842-845.
[6]	Cantiani L,Manara M C,Zucchini C,et al.Caveolin-1 Reduces Osteosarcoma Metastases by Inhibiting c-Src Activity and Met Signaling[J].Cancer Res,2007,67(16):7675-7685.
[9]	Wlliams T M, Lisanti M P. Caveolin-1 in oncogenic transformation,cancer and metastasis[J]. Am J Physiol cell Physiol, 2005, 288(3): C494-506.
[7]	Williams T M,Cheung M W,Park D S,et al.Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice[J].Mol Bool Cell,2003,14(3):1027-1042.
[8]	高万峰,杨光,史昌乾,等.小凹蛋白-1在食管鳞癌中的表达及意义[J].武警医学,2011,22(10):842-845.
[10]	Sunaga N,Miyajima K,Suzuki M, et al. Different Roles for Caveolin-1 in the Development of Non-Small Cell Lung Cancer versus Small Cell Lung Cancer[J].Cancer Res,2004,64:4277-4258.
[9]	Wlliams T M, Lisanti M P. Caveolin-1 in oncogenic transformation,cancer and metastasis[J]. Am J Physiol cell Physiol, 2005, 288(3): C494-506.
[11]	Williams T M, Medina F,Badano I, et al. Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo:role of Cav-1 in cell invasiveness and matrix metalloproteinase(MMP-2/9) secretion[J]. J Biol Chem, 2004,279(2):51630-51646.
[10]	Sunaga N,Miyajima K,Suzuki M, et al. Different Roles for Caveolin-1 in the Development of Non-Small Cell Lung Cancer versus Small Cell Lung Cancer[J].Cancer Res,2004,64:4277-4258.
[11]	Williams T M, Medina F,Badano I, et al. Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo:role of Cav-1 in cell invasiveness and matrix metalloproteinase(MMP-2/9) secretion[J]. J Biol Chem, 2004,279(2):51630-51646.