|
|
Therapeutic effect of human umbilical cord mesenchymal stem cell transplantation on diabetic peripheral neuropathy |
ZHENG Pei1,2,AN Yihua2,WANG Xiaodong2,HUA Rongrong2,ZHU Yan2,and MU Yiming1 |
1. Department of Endocrinology, General Hospital of PLA, Beijing 100853,China;
2. Department of Cell Therapy,The General Hospital of Chinese People’s Armed Police Forces,Beijing 100039,China |
|
|
Abstract Objective To observe the therapeutic effect of human umbilical cord mesenchymal stem cells (HUC-MSCs) transplantation on patients with diabetic peripheral neuropathy. Methods FBG,PBG,HbA1C levels,Toronto clinical scoring system(TCSS),electrophysiological examination were measured in 32 patients with diabetic peripheral neuropathy before and 1,3,6 months after they underwent HUC-MSCs transplantation. Observe the changes of clinical symptoms and the adverse reactions. Results The three follow-up results show that the FBG,PBG,HbA1C levels,TCSS,the distal motor latency of the median nerve,the sensory conduction velocity and the distal motor latency of the ulnar nerve , the positive rate of sensory conduction of the posterior tibial nerve, the distal motor latency and the positive rate of the sensory conduction of the common peroneal nerve all obviously improved. During the study period no adverse reaction occurred.The gross and fine motor function was most rapidly improved in 1 month afer the therapy and it could be continuously improved within 6 months after the therapy. Conclusions HUC-MSCs transplantation can significantly improve the clinical symptoms and electrophysiological examination of patients with diabetic peripheral neuropathy. It is a new safe, effective method to treat diabetic peripheral neuropathy.
|
Received: 13 January 2013
|
|
|
|
|
[1] |
Little A A, Edwards J L ,Feldman E L. Diabetic neuropathies [J]. Pract Neurol, 2007,7: 82-92
|
[1] |
Little A A, Edwards J L ,Feldman E L. Diabetic neuropathies [J]. Pract Neurol, 2007,7: 82-92
|
[2] |
Perkins B A, Bril V, Olaleye D,et al.Simple screening tests for peripheral neuropathy in the diabetes clinic[J].Diabetes Care,2001, 24(2):250 -256.
|
[2] |
Perkins B A, Bril V, Olaleye D,et al.Simple screening tests for peripheral neuropathy in the diabetes clinic[J].Diabetes Care,2001, 24(2):250 -256.
|
[3] |
Brownlee M. Biochemistry and molecular cell biology of diabetic complications [J]. Nature, 2001,41(4):813-820.
|
[3] |
Brownlee M. Biochemistry and molecular cell biology of diabetic complications [J]. Nature, 2001,41(4):813-820.
|
[4] |
沈 薇,董继宏.糖尿病周围神经病的发病机制及治疗展望[J].中国临床神经科学,2008, 16(2): 204-207.
|
[4] |
沈 薇,董继宏.糖尿病周围神经病的发病机制及治疗展望[J].中国临床神经科学,2008, 16(2): 204-207.
|
[5] |
Dejgaard A. Pathophysiology and treatment of diabetic neuropathy [J]. Diabet Med, 1998, 15: 97-112.
|
[5] |
Dejgaard A. Pathophysiology and treatment of diabetic neuropathy [J]. Diabet Med, 1998, 15: 97-112.
|
[6] |
Behse F, Buchthal F, Carlsen F. Nerve biopsy and conduction studies in sural nerves in diabetic neuropathy [J]. Neurol Neurosurg Psychiatty,1977, 40: 1070-1082.
|
[6] |
Behse F, Buchthal F, Carlsen F. Nerve biopsy and conduction studies in sural nerves in diabetic neuropathy [J]. Neurol Neurosurg Psychiatty,1977, 40: 1070-1082.
|
[7] |
谷涌泉,张 建,齐立行,等.自体骨髓干细胞移植治疗下肢神经病变的效果:3例讨论 [J]. 中国临床康复,2005,9(18): 46-48.
|
[7] |
谷涌泉,张 建,齐立行,等.自体骨髓干细胞移植治疗下肢神经病变的效果:3例讨论 [J]. 中国临床康复,2005,9(18): 46-48.
|
[8] |
Kawamoto A, Asahara T, Losordo D W. Transplantation of endothelial progenitor cells for therapeutic neovascul arization [J]. Cardiovasc Radiat Med, 2002, 3( 3-4) : 221-225.
|
[8] |
Kawamoto A, Asahara T, Losordo D W. Transplantation of endothelial progenitor cells for therapeutic neovascul arization [J]. Cardiovasc Radiat Med, 2002, 3( 3-4) : 221-225.
|
[9] |
Busik J V, Tikhonenko M, Bhatwadekar A, et al. Diabeticretinopathy is associated with bone marrow neuropathy and adepressed peripheral clock [J]. Exp Med, 2009, 206(13): 2897-2906.
|
[9] |
Busik J V, Tikhonenko M, Bhatwadekar A, et al. Diabeticretinopathy is associated with bone marrow neuropathy and adepressed peripheral clock [J]. Exp Med, 2009, 206(13): 2897-2906.
|
[10] |
Schmidt R E, Dorsey D A, Beaudet L N, et al. Insulin-like growth factor I reverses experimental diabetic autonomic neuropathy [J] . Pathol, 1999, 155(5): 1651-1660.
|
[10] |
Schmidt R E, Dorsey D A, Beaudet L N, et al. Insulin-like growth factor I reverses experimental diabetic autonomic neuropathy [J] . Pathol, 1999, 155(5): 1651-1660.
|
[11] |
Lakshmipathy U, Verfaillie C. Stem cell plasticity [J]. Blood Rev, 2005, 19(1): 29-38.
|
[11] |
Lakshmipathy U, Verfaillie C. Stem cell plasticity [J]. Blood Rev, 2005, 19(1): 29-38.
|
[12] |
Lange C, Schroeder J, Stute N, et al. High-potential human mesenchymal stem cells [J] . Stem Cells Dev, 2005, 14(1): 70-80.
|
[12] |
Lange C, Schroeder J, Stute N, et al. High-potential human mesenchymal stem cells [J] . Stem Cells Dev, 2005, 14(1): 70-80.
|
[13] |
Tepper O M, Galiano R D, Capla J M, et al. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures [J] .Circulation, 2002, 106(22): 2781-2786.
|
[13] |
Tepper O M, Galiano R D, Capla J M, et al. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures [J] .Circulation, 2002, 106(22): 2781-2786.
|
[14] |
Wang H S, Hung S C, Peng S T, et al. Mesenchymal stem cells in the wharon’s jelly of the human umbilical cord [J]. Stem Cells, 2004, 22(7): 1330-1337.
|
[14] |
Wang H S, Hung S C, Peng S T, et al. Mesenchymal stem cells in the wharon’s jelly of the human umbilical cord [J]. Stem Cells, 2004, 22(7): 1330-1337.
|
|
|
|