旋毛虫感染对过敏性哮喘小鼠血清总IgE、IL-4、IL-5的影响

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Abstract Objective To study the effect of Trichinella spiralis infection on total IgE, IL-4 and IL-5 in serum of the mice with allergic asthma. Methods Twenty female BALB/c mice were randomly divided into four groups of five mice each, including Ⅰ as control group, Ⅱ as allergic asthma group, Ⅲ as asthma followed by Trichinella spiralis infection, Ⅳ as Trichinella spiralis infected group. Firstly, the animals in group Ⅲ and Ⅳ were infected with 200-300 Trichinella spiralis muscle larvae. Twenty-eight days later, ovalbumin (OVA) was used to induce the allergic asthma for mice in group Ⅱ and Ⅲ, in order to establish asthma animal model. After 56 days, all mice were sacrificed, levels of TIgE, IL-4 and IL-5 in serum were measured by ELISA. Results The TIgE levels in groupⅠ,Ⅱ,Ⅲ and Ⅳ were (61.79±25.79) ng/ml,(437.08±75.68) ng/ml, (251.64±107.27) ng/ml and (446.12±74.32)ng/ml, respectively. The IL-4 levels in groupⅠ,Ⅱ, Ⅲ and Ⅳ were (136.49±31.17) pg/L, (209.80±21.57) pg/L, (162.79±17.69) pg/L and (182.71±12.08)pg/L, respectively. IL-5 levels in groupⅠ,Ⅱ, Ⅲ and Ⅳ were (7.31±1.86) ng/L, (16.00±2.29) ng/L,(9.24±1.73) ng/L and (11.41±2.11)ng/L, respectively. Compared with group Ⅱ, the TIgE、IL-4 and IL-5 levels in group Ⅲ decreased (P<0.05). Conclusions Trichinella spiralis infection can inhibit expression of the TIgE, IL-4 and IL-5 in serum of mice with allergic asthma

Key words： Trichinella spiralis allergic asthma TIgE cytokines

Received: 02 July 2013

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	MA Ping
	YAN Yuwen
	and BAO Chunyu.

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MA Ping,YAN Yuwen,and BAO Chunyu.. Experimental study on changes of serum total IgE, IL-4 and IL-5 in mice with Trichinella spiralis induced allergic asthma[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2013, 24(6): 502-504.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2013/V24/I6/502

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[1]	. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(4): 409-412.