小剂量长效干扰素联合利巴韦林治疗肝移植术后丙肝复发

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Abstract Objective To study therapy efficacy of small dose peg-interferon plus ribavirin on recurrent Hepatitis C patients of post liver transplantation. Methods The patients were accepted the therapy of Pegasys 90ug/week, after two weeks 135 ug/week,Ribavirin 600mg/day, who were recurrence with Hepatitis C post liver transplantation from June, 2002 to April, 2012 in our hospital. The titer of HCV-RNA, liver function, blood routine and clinical presents were monitoring at 6th week, 12 th week and 24th week during the therapy. Results There were 22 cases were accepted the therapy of small dose peg-interferon plus ribavirin. The rate of early virological response(EVR) was 90.9%. The rate of end-of-treatment virological response(ETVR) was 100.0%. The sustained virological response (SVR) was 81.8%. There was significant increase of the activity of cholinesterase after 24 weeks treatment (P=0.013). The mild abnormality was taken place in the blood routine, hemoglobin 54.5%, platelet 68.2% and leucocyte 27.3%. Severe fever, skin lesion and alopecia were not taken place in these cases. Conclusions The rates of EVR, ETVR and SVR are high, and the liver synthetic ability of patients are elevated without serious side-effect after treated small dose peg-interferon plus ribavirin.

Received: 02 July 2013

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	Articles by authors
	FAN Tieyan
	CHEN Hong
	SHEN Zhongyang
	TIAN Yan
	and YANG Yang

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FAN Tieyan,CHEN Hong,SHEN Zhongyang等. The therapy efficacy of small dose peg-interferon plus ribavirin on recurrent Hepatitis C patients of post liver transplantation[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2013, 24(6): 507-510.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2013/V24/I6/507

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