第四代HIV诊断试剂检测HIV抗体假阳性原因分析

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Abstract Objective To study the causes of false positive results in the fourth generation p24 Ag/anti-HIV combined assay and cut down the false positive results. Methods We picked 119 samples which were reactive in HIV-Ab screening test with the fourth generation HIV assay, then confirmed these samples with West-blot assay and compared them. Results In 119 reactive samples, 40 samples were HIV-1 positive, 28 samples were HIV-Ab indeterminate, and 51 samples were HIV-Ab negative. The higher the S/CO index, the closer the positive results of screening test related to one of confirmatory test. Conclusions The rate of false positive is high with the fourth generation HIV assay, which is relative to the combined detection of anti-HIV-P24. When 1<S/CO≤10, we should consider comprehensive factors such as history of disease, the clinical symptoms, etc.

Key words： antibody to HIV HIV-1 P24 antigen the fourth generation HIV assay false positive reaction

Received: 10 April 2013

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	Articles by authors
	GU Chun-Yu
	LIU Ying-Li
	WANG Hai-Bin
	SUN Ting-Ting
	HE Li-Jing

Cite this article:

GU Chun-Yu,LIU Ying-Li,WANG Hai-Bin等. Causes of false-positive results in p24 Ag/anti-HIV combined assay[J]. , 2013, 24(9): 758-760.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2013/V24/I9/758

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