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| Clinical characteristics of hepatitis B vaccination in prophylaxis in patients transplanted for HBV-related disease |
| GAO Yinjie,LIU Zhenwen,ZHANG Min,SU Haibin,ZHOU Shuangnan,and ZHOU Xia. |
| Center of Liver Transplantation, 302 Hospital of PLA, Beijing 100039, China |
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Abstract Objective To study the clinical characteristics after hepatitis B vaccination in liver transplant patients for hepatitis B virus (HBV) related diseases and analyze the factors that influence the response. Methods Nine patients received three intramuscular doses (60ug) of a recombinant vaccine at months 0, 1, 2 and 6 and the anti-HBs titers were tested regularly. Results Overall sustained response to vaccination was 22.2 % (2/9), which were completely free of HBIG at the end of the six months follow-up. Three patients had part response, which reduced the amount of HBIG. Four patients had no response. Conclusions Hepatitis B vaccination is one of the prophylaxis of HBV recurrence to the liver transplant patients for HBV related diseases. Anti-HBsAb level at time of vaccination probably yields good response.
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Received: 21 April 2013
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2013, Vol. 24 
