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| Effects of resveratrol on serum inflammatory cytokines in rats with severe acute pancreatitis |
| QIAN Xiufang,GUO Zhe,HU Changju,and ZHANG Xuemei. |
| Department of Pharmacy, the Second Hospital of Beijing Municipal Corps, Chinese People’s Armed Police Forces, Beijing 100037, China |
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Abstract Objective To investigate the effects of resveratrol (Res) on expression of serum inflammatory cytokines in rats with severe acute pancreatitis (SAP). Methods SAP model was induced by intraductal administration of 5% taurocholic acid sodium salt. SD rats were then randomly divided into 3 groups (n=16), namely normal, model and Res group (5, 10 and 20 mg/kg). Drugs were administered via caudal vein 30 min post-operation. The levels of TNF-α, IL-1 and IL-6 in serum were measured by ELISA, and pancreatic histological changes were observed under microscope 6 h and 12 h post-operation. Resluts Res veratrol evidently reduced the severity of pancreatic pathology in rats with SAP, compared with model group (P<0.01). Res veratrol significantly inhibited the levels of TNF-α [(89.0±19.2), (84.7±16.0)and (105.6±22.3) ng/L, respectively], IL-1 [(109.3±19.8), (114.5±30.2) and (135.5±29.2) ng/L, respectively] and [IL-6 (185.3±28.8), (201.5±44.0) and (213.0±30.7) ng/L, respectively] in serum 6 h post-operation (P<0.05 or P<0.01), and those of TNF-α, IL-1 and IL-6 12 h post-operation (P<0.01). Conclusions Res veratrol can inhibit the expression of inflammatory cytokines, and protect rats with SAP effectively.
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Received: 05 December 2013
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2013, Vol. 24 
