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| Expression and significance of estrogen receptor and 17beta-hydroxysteroid dehydrogenase 1 in endometrial polyps |
| XIAO Pei1,ZHANG Cuiling2,SUN Li3,and WANG Shuhe4 |
| 1. Clinical School of Anhui Medical University, Hefei 230000, China; 2.Department of Obstetrics and Gynecology, Chinese Medicine Hospital of Linyi City, Linyi 276003, China; 3.Department of Gynecology and Obstetrics, Hefei Municipal First People’s Hospital, Hefei 230000, China; 4. Department of Gynecology and Obstetrics, Beijing Military Command General Hospital, Beijing 100700, China |
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Abstract Objective To study the expressions of ER and 17β-HSD1 in endometrial polyps, and to clarify the pathogenesis of endometrial polyps in molecular level. Methods Endometrial polyps from 47 patients were taken as the study group; at the same time, normal endometrial tissue far from endometrial polyps were taken from the same 47 patients as the control group 1 and normal endometria from 50 subjects were taken as the control group 2 who underwent hysteroscopy. Immunohistochemical examination was conducted to detect ER and 17β-HSD1 expressions which were compared between the groups. Results The positive expression rate of ER in polyps group was 80.9%, which was 76.6% for 17β-HSD1. The rates were higher than those of the control group(P＜0.01). The expressions of ER and 17β-HSD1 were related to the risk of endometrial polyps(r=0.619, P＜0.01). Conclusions Excessive expressions of ER and 17β-HSD1 in premenopausal endometrial polyps may be the cause of occurrence and development of endometrial polyps.
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Received: 03 September 2013
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| [1] |
. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(6): 541-544. |
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2014, Vol. 25 
