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| Role of atosiban and naloxone in analgesic effects of oxytocin |
| WEI Xiaojie1,GUO Qulian2,and ZHANG Yanfeng2 |
1.Department of Anesthesiology, Hunan Provincial Corps Hospital,Chinese People’s Armed Police Forces, Changsha 410006,China;
2.Xiangya Hospital of Central South University, Changsha 410008,China |
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Abstract Objective To study the role of atosiban and naloxone in the analgesic effects of oxytocin (OT). Methods Male SD rats were divided randomly into 2 groups, i.th group and i.c.v group. And both groups subdivided as below: N.S+OT (control group, C);atosiban + OT low, medium and high dose groups;naloxone + OT low, medium and high dose groups. And the mechanical pain threshold was tested 10 min,30 min,1 h,3 h,6 h,12 h,24 h after incision in all of the rats. Results I.th and i.c.v administration of atosiban could thoroughly inhibit the analgesia effect of OT(P<0.05); compared with control group, the pain threshold of rats with naloxone only decreased after low and medium doses of OT(P<0.05); the pain threshold had no significant differences between the high dose OT treated rats and the control group(P＞0.05). Conclusions The analgesic effect of OT can be totally inhibited by i.t.h or i.c.v atosiban, but partly depressed by naloxone.
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Received: 25 December 2013
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2014, Vol. 25 
