异丙酚联合不同剂量芬太尼对日间手术麻醉深度

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Abstract Objective To study the offect of propofol combined with different doses of fentanyl on the depth of anesthesia and hemodynamics during outpatient surgery, seek for the suitable dose of compound fentanyl analgesia.Methods Eighty outpatient surgical patients (ASA Ⅰ~Ⅱ class)were randomly divided into four groups: propofol was simply used in group Ⅰ, fentanyl was intravenously injected 0.50 μg/kg in group Ⅱ, fentanyl was injected intravenously 0.75 μg/kg in group Ⅲ,fentanyl intravenously injected 1.00 μg/kg in group Ⅳ; then propofol was slowly injected intravenously in each group to the BIS (bispectral index) values to 50(disappearance of eyelash reflex), surgery began after 1 minute,and additional propofol according to response of the stimulation in patients, maintained BIS between 40-50.①The data of BIS,HR (heart rate), BP (blood pressure), SPO₂ (arterial oxygen saturation), and ECG (electrocardogram, ECG) were recorded at time of premedication disappearance of eyelash reflex, starting operation or surgical procedure, end of the operation and waking up.②Waking up time, body movements and propofol dose were also recorded.Results (1)T1-T4 BIS had no significant differences between four groups. Waking time and recovery time of orientation in group Ⅳ was prolonged than those in groups Ⅰ, Ⅱ, Ⅲ (P<0.05). (2) Propofol doses in group Ⅱ, Ⅲ, Ⅳ were obviously lower than that in group Ⅰ (P<0.01). Physical movements response in group Ⅱ, Ⅲ, Ⅳ were lower than that in group Ⅰ (P<0.05). (3) Decrease of NIBP, SPO₂ in group Ⅳ was more significant than in groups Ⅰ,Ⅱ, Ⅲ (P<0.05). Conclusions Intravenous anesthesia with fentanyl combined with propofol(0.75 μg/kg) is safe,effective, and inexpensive with short wakeing up time for outpatient surgery.

Key words： propofol fentanyl outpatient surgery bispectral index

Received: 25 March 2014

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2014/V25/I9/892

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