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| Research on the therapeutic effect of Vitamin D3 in gestational diabetes factor |
| HOU Xuejing and LU Chunmei |
| Department of Gynecology,Qinhuangdao First Hospital, Qinhuangdao 066000,China |
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Abstract Objective To explore the effect of Vitamin D3 in gestational diabetes inflammation factor. Methods Sixty patients with gestational diabetes were randomly divided into two groups:30 cases of control group (treatment group), 30 cases of observation group (foundation treatment group plus vitamin D3). On the basis of the control group, treatment observation group was given oral vitamin D3 1000 U/d for 4 weeks. Before and after treatment, high-sensitivity c-reactive protein (Hs-CRP), tumor necrosis factor alpha and insulin resistance were compared between two groups. Results Before and after treatment ,observation group hs-CRP (mg/L) was decreased obviously, respectively 6.18±2.99,3.80±1.60; control group was 5.78±2.24, 5.05±1.90. There was statistically significant difference (P<0.05). Before and after treatment ,observation group TNF-α(pg/ml) was decreased obviously, respectively 36.33±5.45,27.45±5.01;control group was 40.25±19.25,35.35±14.50. There was statistically significant difference (P<0.05).After treatment, insulin resistance of observation group was improved (P<0.05). Conclusions High Vitamin D3 level in blood can improve glucose metabolism during pregnancy through increasing insulin sensitivity.
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Received: 22 July 2014
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Cutolo M, Pizzorni C, Sulli A. Vitamin D endocrine system involvement in autoimmune rheumatic diseases[J]. Autoimmun Rev, 2011,11(2):84-87.
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Zhang C, Qiu C, Hu F B, et al. Maternal plasma 25-hydroxyvitamin D concentration and the risk for gestational diabetes mellitus[J].PLoS One, 2008, 3(11):1-6.
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Nazarian S, St Peter J V, Boston R C, et al. Vitamin D3 supplementation improves insulin sensitivity in subjects with impaired fasting glucose[J].Transl Res,2011,158(5):276-281.
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2014, Vol. 25 
