泪腺腺样囊性癌S-100蛋白、神经细丝酸性蛋白的表达及其意义

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (4750 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the expression of Schwann's cell markers S-100 and GFAP in lacrimal adenoid cystic carcinoma, and to explore the relationship between GFAP or S-100 expression and neural invasion of adenoid cystic carcinoma. Methods Twenty-eight lacrimal adenoid cystic carcinoma and 9 normal lacrimal gland specimens were collected . Each specimen was stained by S-P(streptavidin/peroxidase) immuno- histochemical staining. The expression of S-100 and GFAP was analyzed by immunohistochemistry in order to find the difference in the above-mentioned tissues. One-way ANOVA, Student,s test, chi-square test or linear correlation were carried out for statistical evaluation. Results The average S-100 Index(S-100LI) in nor-neural invasion group and neural invasion group were 0.62±1.19 and 16.73±24.74,respectively,in lacrimal gland adenoid cystic carcinoma. (P<0.05). The average GFAP LI in nor-neural invasion group and neural invasion group were 0 and 2.07±3.01,respectively,in lacrimal gland adenoid cystic carcinoma. (P<0.05). Conclusions Schwann’s cell markers GFAP and S-100 in neural invasion group is higher than that in nor-neural invasion group (P<0.05). The Schwann’s cell differentiation may account histologically for the neural invasion of lacrimal gland adenoid cystic carcinoma.

Key words： lacrimal adenoid cystic carcinoma S-100 glial fibrillary acidic protein neural invasion immunohistochemistry

Received: 12 January 2014

ZTFLH:

R777.5

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Leifeng
	DONG Yuping
	ZHU Sufang
	LI Xiaojuan
	DONG Qiuyan
	and HEI Yan

Cite this article:

WANG Leifeng,DONG Yuping,ZHU Sufang等. Expression and significance of S-100 and GFAP in lacrimal adenoid cystic carcinoma[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2014, 25(12): 1252-1255.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2014/V25/I12/1252

[9]	范莹,耿美玉,张均田.神经细胞粘附分子与硫酸化氨基聚糖在神经发育、轴突生长、突触可塑性及学习和记忆中的作用[J].生理科学进展,2002,33(4):370-373.
[1]	吕春堂,周树夏.涎腺腺样囊性癌热点问题研究 [J].第二军医大学学报,2005,26(6):589-592.
[2]	Azadeh A, Soheil P, Zohreh J, et al. Expression of Ki67 and CD105 as Proliferation and Angiogenesis Markers in Salivary Gland Tumors3 [J]. Asian Pacific Journal of Cancer Prevention, 2012,13(10):5155-5159.
[10]	Toshitaka N, Eiichi S, Rie I,et al. Immunohistochemical Analysis of Salivary Gland Tumors: Application for Surgical Pathology Practice[J]. Acta Histochem, 2012,45 (5): 269-282.
[3]	Tang W, Hei Y, Xiao L. Recurrent orbital space-occupying lesions: a clinicopathologic study of 253 cases[J]. Chin J Cancer Res, 2013,25(4):423-429.
[11]	Tieu K,Yu P H. Neural cell adhesion molecules. In: Boultin AA,Baker GB,Bateson AN. Neuromet hods vol 33 : cell neurobiology techniques [M]. New Jersey:Humana press, 1999:103-107.
[4]	Bhavna C, Seema K, Seema S, et al. Clinicopathologic Review of Epithelial Tumors of the Lacrimal Gland3 [J]. Ophthal Plast Reconstr Surg,2013, 29(6): 440-445.
[12]	HO H, Lim Z, Kh T, et al. Bilateral kutter tumors of the lacrimal glands[J]. Orbit, 2011,30(2):96-97.
[5]	Zeng J, Shi J T, Li B, et al. Epithelial tumors of the lacrimal gland in the Chinese: a clinicopathologic study of 298 patients[J]. Graefes Arch Clin Exp Ophthalmol, 2010,248:1345-1349.
[13]	Gandour R,Kapadia S B,Barnes L,et al. Cell adhesion molecule in adenoid cystic carcinoma invading the skull base [J]. Otolaryngol Head Neck Surg,1997,117(5):453-458.
[6]	Toth A,Daley T D.Schwann cell differentiation of modified myoepithelial cells within adenoid cystic carcinomas and polymorphous low-grade adenocarcinomas [J]. J Otolaryngol, 1996, 25(2):94-102.
[7]	Iwamoto S,Burrows R C.The p75 neurotrophin receptor,relative to others Schwann cell and melanoma markers,is abundantly expressed in spindled melanomas[J].Am J Dermatopathol,2001,23(4):288-294.
[8]	罗小龙,孙沫逸, 杨连甲,等. 雪旺细胞标志物S-100蛋白在涎腺腺样囊性癌嗜神经侵袭中的意义[J].实用口腔医学杂志,2003,19(2):173-175.
[9]	范莹,耿美玉,张均田.神经细胞粘附分子与硫酸化氨基聚糖在神经发育、轴突生长、突触可塑性及学习和记忆中的作用[J].生理科学进展,2002,33(4):370-373.
[10]	Toshitaka N, Eiichi S, Rie I,et al. Immunohistochemical Analysis of Salivary Gland Tumors: Application for Surgical Pathology Practice[J]. Acta Histochem, 2012,45 (5): 269-282.
[11]	Tieu K,Yu P H. Neural cell adhesion molecules. In: Boultin AA,Baker GB,Bateson AN. Neuromet hods vol 33 : cell neurobiology techniques [M]. New Jersey:Humana press, 1999:103-107.
[12]	HO H, Lim Z, Kh T, et al. Bilateral kutter tumors of the lacrimal glands[J]. Orbit, 2011,30(2):96-97.
[13]	Gandour R,Kapadia S B,Barnes L,et al. Cell adhesion molecule in adenoid cystic carcinoma invading the skull base [J]. Otolaryngol Head Neck Surg,1997,117(5):453-458.