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| Association of IL-6 gene promoter region -643C/G polymorphism with diabetic retinopathy |
| AN Xinhuan1,LANG Ganxiong1, and WU Huijuan2 |
1.Department of Diabetes,Zhongshan People’s Hospital, Zhongshan 528400, China;
2. Beijing Physical and Chemical Analysis and Testing Center, Beijing 100094,China |
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Abstract Objective To investigate the association of IL-6 gene promoter region -643C/G polymorphism with diabetic retinopathy. Methods The polymorphism of IL-6 gene promoter region -634 C/G in 245 unrelated Guangdong Han people with type 2 diabetes ,including 153 cases without diabetic retinopathy (DR0 group) ,51 cases without proliferative diabetic retinopathy (NPDR)(DR1 group), 41 cases with proliferative diabetic retinopathy (PDR) (DR2 group), and 101 normal controls(NC group) were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods. The genotype frequency, allele frequency and relative clinical data were compared between groups. Results (1)There were no significant differences in the clinical characteristics except for diabetic duration among DR0, DR1, DR2 groups. (2) The frequencies of IL-6-643 G/G genotype and G allele frequencies among DR0 DR1 DR2 groups were statistically different. There were significantly different in GG genotype between DR0 and DR group,comparison between any two means were not significant differences in G allele frequencies.(3) Logistic regression analysis showed that IL-6 gene promoter region-643G/G genotype,fasting plasma glucose and diabetic duration were risk factors of DR. Conclusions The IL-6 promoter region-643G/G genotype may be a genetic risk factor of DR development.
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Received: 10 April 2014
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彭湾湾,曾姣娥.PEDF IL-6与2型糖尿病视网膜病变的临床研究[J].医学研究杂志,2013,42(10):155-157.
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周 林,孙 昊,徐 岬,等.VEGFIL-6的水平与糖尿病视网膜病变关系的研究[J].眼科学报,2010,25(1):26-30.
|
| [6] |
Funatsu H, Yamashita H, Noma H, et al.Aqueous humor levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients[J].Graefes Arch Clin Exp Ophthalmol,2005,243(1):3-8.
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蒋 玲,吕红彬.细胞因子与糖尿病视网膜病变的研究进展[J].眼科研究,2009,27(12):1166-1167.
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张 洁,王伟超,刘素波,等.不同分期糖尿病视网膜病变泪液IL- 6的表达[J].中国现代医学杂志,2012,22(14):51-54.
|
| [8] |
Carin, Gustavsson,Carl D,et al.Profile of intraocular tumour necrosis factor-α and interleukin-6 in diabetic subjects with different degrees of diabetic retinopathy [J]. Acta ophthalmologica, 2013,91(5):445-452.
|
| [9] |
彭湾湾,曾姣娥.PEDF IL-6与2型糖尿病视网膜病变的临床研究[J].医学研究杂志,2013,42(10):155-157.
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蒋 玲,吕红彬.细胞因子与糖尿病视网膜病变的研究进展[J].眼科研究,2009,27(12):1166-1167.
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2014, Vol. 25 
