|
|
|
| Low dose of low molecular weight heparin for prevention of lower extremity deep vein thrombosis after hypertensive intracerebral hemorrhage operation |
| JIANG Tao,FENG Jialong,LIU Zhonghong,RAN Chunlei, ZHANG Jiezhi,and TAN Chun |
| Department of Neurosurgery, Chongqing Municipal Corps Hospital,Chinese People’s Armed Police Forces, Chongqing 400061, China |
|
|
|
|
Abstract Objective To evaluate the outcome of low molecular weight heparin (LMWH) for the prevention of lower extremity deep vein thromboembolism (LDVT) in patients with hypertensive intracerebral hemorrhage after operation. Methods 82 patients with hypertensive intracerebral hemorrhage after operation were divided into two groups: prothylactic group (n=42) and control group (n=40). The patients in prothylactic group were injected hypodermically with LMWH from day 3 to day 14 after operation and treated with intermittent pneumatic compression from 1 to 21 days continuously. Whereas the patients in control group were treated only by intermittent pneumatic compression. The plasma D-dimer (D-D) was measured in all patients before operation and was determined at day 7, 14, 21 after operation. The deep veins of lower limbs in all patients were examined with colour Doppler at day 7, 14, 21 after operation to observe venous thromboembolism. Results Only one case of deep vein thrombosis in prothylactic group(2.38%), and one cerebral hemorrhage(2.38%)recurred. In control group, deep vein thrombosis was found in 9 cases(22.50%), and one cerebral hemorrhage(2.50%) recurred, and one pulmonary embolism(2.50%)was found. The DVT incidence between two groups was significantly different(P＜0.05), but the PTE incidence was not significantly different. D-D content at days 7, 14 after operation in control group was significantly higher than that in prophylactic group (P＜0.05), but the D-D level had no significant difference before operation and at day 21 after operation between the two groups. Conclusions LMWH is safe and effective for the prevention of LDVT in patients after hypertensive intracerebral hemorrhage operation.
|
|
Received: 05 June 2014
|
|
|
|
|
|
| [5] |
Gregory P C, Kuhlemeier K V. Prevalence of venous thromboembolism in acute hemorrhagic and thromboembolic stroke [J]. Am J Phys Med Rehabil, 2003, 82(5): 364-369.
|
| [1] |
Asch V,Luitse M J, Rinkel G J, et al. Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age,sex,and ethnic origin;a systematic review and meta-analysis[J]. Lancet Neuron,2010, 9(2):167-176.
|
| [6] |
Lacut K,Bressollette L, Le Gal G, et al. Prevention of venous thrombosis in patients with acute in tracerebral hemorrhage [J]. Neurology, 2005, 65(6): 865-869.
|
| [2] |
Smith S D, Eskey C J. Hemorrhagic stroke [J]. Radiol Clin North Am, 2011, 49(1): 27-45.
|
| [3] |
Novielli N, Sutton A J, Cooper N J. Meta-analysis of the accuracy of two diagnostic tests used in combination: application to the dimer test and the wells score for the diagnosis of deep vein thrombosis [J]. Value Health, 2013, 16(4): 619-628.
|
| [7] |
Ogata T,Yasaka M, Wakugawa Y, et al. Deep venous thrombosis after acute intra-cerebral hemorrhage [J]. J Neurol Sci, 2008, 272(1-2): 83-86.
|
| [8] |
Bembenek J, Karlinski M, Kobayashi A. Early stroke-related deep venous thrombosis: risk factors and influence on outcome [J]. J Thromb Thrombolysis, 2011, 32(1): 96-102.
|
| [4] |
Paciaroni M, Agnelli G, Venti M, et al. Efficacy and safety of anticoagulants in the prevention of venous thromboembolism in patients with acute cerebral hemorrhage: a meta-analysis of controlled studies [J]. J Thromb Haemost, 2011, 9(5): 893-898.
|
| [9] |
Bamford J, Dennis M, Sandercock P, et al. The frequency, causes and timing of death within 30 days of a first stroke: the Oxfordshire Community Stroke Project [J]. J Neurol Neurosurg Psychiatry, 1990, 53(10): 824-829.
|
| [5] |
Gregory P C, Kuhlemeier K V. Prevalence of venous thromboembolism in acute hemorrhagic and thromboembolic stroke [J]. Am J Phys Med Rehabil, 2003, 82(5): 364-369.
|
| [10] |
周志武,周 静,张海琴,等. 血浆D-二聚体在高血压脑出血变化的研究[J]. 陕西医学杂志,2013,42(9): 1234-1236.
|
| [6] |
Lacut K,Bressollette L, Le Gal G, et al. Prevention of venous thrombosis in patients with acute in tracerebral hemorrhage [J]. Neurology, 2005, 65(6): 865-869.
|
| [11] |
顾双双, 沙杜鹃,张 均, 等. 脑出血合并静脉血栓栓塞的预防和治疗[J]. 国际脑血管病杂志, 2012, 20(7): 513-518.
|
| [7] |
Ogata T,Yasaka M, Wakugawa Y, et al. Deep venous thrombosis after acute intra-cerebral hemorrhage [J]. J Neurol Sci, 2008, 272(1-2): 83-86.
|
| [12] |
Morgenstern L B, Hemphil J C 3rd, Anderson C, et al. Guidelines of the management of spontaneous intracerebral hemorrhage:a guideline for healthcare professionals from the American Heart Association/American Stroke Association[J]. Stroke, 2010, 41(9): 2108-2129.
|
| [8] |
Bembenek J, Karlinski M, Kobayashi A. Early stroke-related deep venous thrombosis: risk factors and influence on outcome [J]. J Thromb Thrombolysis, 2011, 32(1): 96-102.
|
| [13] |
Mittal M K, Rabinstein A A. Anticoagulation-related intracranial hemorrhages [J]. Curr Atheroscler Rep, 2012, 14(4): 351-359 .
|
| [9] |
Bamford J, Dennis M, Sandercock P, et al. The frequency, causes and timing of death within 30 days of a first stroke: the Oxfordshire Community Stroke Project [J]. J Neurol Neurosurg Psychiatry, 1990, 53(10): 824-829.
|
| [10] |
周志武,周 静,张海琴,等. 血浆D-二聚体在高血压脑出血变化的研究[J]. 陕西医学杂志,2013,42(9): 1234-1236.
|
| [11] |
顾双双, 沙杜鹃,张 均, 等. 脑出血合并静脉血栓栓塞的预防和治疗[J]. 国际脑血管病杂志, 2012, 20(7): 513-518.
|
| [12] |
Morgenstern L B, Hemphil J C 3rd, Anderson C, et al. Guidelines of the management of spontaneous intracerebral hemorrhage:a guideline for healthcare professionals from the American Heart Association/American Stroke Association[J]. Stroke, 2010, 41(9): 2108-2129.
|
| [13] |
Mittal M K, Rabinstein A A. Anticoagulation-related intracranial hemorrhages [J]. Curr Atheroscler Rep, 2012, 14(4): 351-359 .
|
| [1] |
. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(8): 711-712. |
|
|
|
|
2014, Vol. 25 
