右美托咪定与芬太尼用于经皮微波消融治疗肝癌麻醉的比较

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Abstract Objective To compare the anesthetic effect of propofol combined with dexmedetomidine or fentanyl in ultrasonically guided percutaneous microwave coagulation therapy (PMCT) for hepatocellular carcinoma (HCC). Methods Forty HCC patients (ASAⅠ-Ⅱ) were allocated randomly to two groups with 20 cases each. The patients in group F received intravenous anesthesia with fentanyl combined with propofol, and the patients in group D received intravenous anesthesia with dexmedetomidine combined with propofol during PMCT for HCC. The consumption of propofol, recovery time, BP, HR, SpO₂ and complications were assessed. VRS and patient’s satisfactions were assessed at 30 minutes after PMCT. Results The consumption of propofol in group D decreased more than that in group F (P<0.01). The recovery time in group F decreased more than that in group D (P<0.01). The changes of SBP, DBP and HR were more in group F than those in group D (P<0.05). The incidences of bradycardia, hypotension, apnoea and injection pain in group F were higher than those in group D (P<0.05). At 30 min after PMCT, VRS in group D decreased more than that in group F (P<0.01). The patient’s satisfactions in group F decreased more than that in group D (P<0.05). Conclusions Propofol combined with dexmedemidine or fentanyl provides satisfactory anesthesia for the operation of HCC with ultrasonically guided PMCT, but anesthesia with dexmedemindine increases recovery time and patient’s satisfactions, decreases consumption of propofol and adverse reactions, and has less effect on the respiratory and circulatory function than that with fentanyl.

Key words： dexmedetomidine fentanyl propofol percutaneous microwave coagulation therapy hepatocellular carcinoma

Received: 10 June 2014

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	LU Zhonghui
	ZHOU Yigang
	XU Jun

Cite this article:

LU Zhonghui,ZHOU Yigang,XU Jun. Anesthetic effect of dexmedetomidine or fentanyl in ultrasonically guided percutaneous microwave coagulation therapy for hepatocellular carcinoma[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2014, 25(10): 1018-1020.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2014/V25/I10/1018

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