老年慢性心力衰竭患者甲状腺激素的变化及其临床意义

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Abstract Objective To investigate the changes and clinical significance of thyroid hormones function in elderly patients with chronic heart failure. Methods A total of 76 elderly patients with chronic heart failure were divided into different groups according to NYHA categorization: NYHA Ⅱ group (25 patients), NYHA Ⅲ group (28 patients) and NYHA IV group (23 patients). Thirty non-heart failure elderly subjects served as control group. T₃, T₄, FT₄, FT₃, TSH were tested by radioimmunoassay. Results Compared with T₃ and FT₃ levels [(2.34±0.52)nmol/L and (4.27±0.64) pmol/L respectively] in control group, T₃ and FT₃ levels[(1.28±0.51) nmol/L and (3.01±0.78) pmol/L respectively] in NYHAⅡ group were decreased (P＜0.05); and with the deterioration of cardiac function functional class Ⅲ-Ⅳ (P＜0.01), patients showed T₃ and FT₃ levels [ (0.87±0.43) nmol/L and (2.42±0.61) pmol/L respectively] in NYHA Ⅲ group, and [ (0.60±0.36) nmol/L and (2.09±0.71) pmol/L respectively ] in NYHA IV group. Conclusions T₃ and FT₃ play an important role in chronic heart failure, can serve as the early predictors in elderly patients with chronic heart failure.

Key words： elderly patients chronic heart failure thyroid hormones clinical significance

Received: 25 April 2014

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2014/V25/I10/997

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