黄芩苷与红景天胶囊对急性高原病预防作用比较

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Abstract Objective To investigate the effect of baicalin capsules for acute mountain sickness(AMS) prevention with rapid airlift ascent to high altitude. Methods A randomized controlled trial was conducted on 80 healthy young men with baicalin capsules (0.5 g bid, n=32), rhodiola capsules (0.76 g bid, n=24), or placebo (n=24), for 2 days prior to airlift ascent (397 m) and for the first 3 days at high altitude (3658 m). AMS, oxygen saturation (SpO₂), heart rate (HR), systolic blood pressure(SBP), diastolic blood pressure(DBP), pulmonary artery systolic pressure (PASP) and mean pulmonary arterial pressure (MPAP) were assessed both at 397 m and 3658 m. Results After high-altitude exposure, significantly fewer participants in the baicalin capsules group(n=8, 25.0%) and rhodiola capsules group(n=7, 29.2%) developed acute mountain sickness compared with participants receiving placebo (n=14, 58.3%) (P<0.05) . HR, SBP, DBP, PASP and MPAP increased with altitude exposure (P<0.05), and SpO₂ decreased with altitude exposure (P<0.05). AMS, HR, SBP and DBP with baicalin capsules was lower than those with placebo (P<0.05); AMS, PASP, MPAP with rhodiola capsules were lower than those with placebo (P<0.05) and SpO₂ was higher than that with placebo (P<0.05). Conclusions Baicalin capsules for AMS prevention also reduce HR, SBP and DBP with rapid airlift ascent to high altitude and rhodiola capsules for AMS prevention also reduce PASP, MPAP, increase SpO₂ with rapid airlift ascent to high altitude.

Key words： acute mountain sickness baicalin capsules rhodiola capsules blood pressure pulmonary artery systolic pressure

Received: 28 July 2014

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	Articles by authors
	DUAN Wei
	SUN Shuhong
	HUI Zengqian
	GAO Zhao
	HU Jianku
	JIN Feng
	CHEN Hong

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DUAN Wei,SUN Shuhong,HUI Zengqian等. Effect of baicalin capsules on acute mountain sickness in healthy young males at acute high altitude exposure[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(1): 75-78.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2015/V26/I1/75

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