烧伤脓毒症患者外周C-反应蛋白和CD64水平动态变化

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Abstract Objective To study the peripheral C- reactive protein and CD64 level dynamic change in patients with early burn and sepsis. Methods A total of 80 burn patients were collected in this hospital from 2013 January to 2014 January in burn department. According to the diagnosis, they of burn sepsis were divided into 2 groups, burn sepsis group (40 cases) and control group (40 cases). After admission, two groups of patients were promptly given antibiotics to prevent infection, fluid infusion, anti shock, wound dressing changed actively, maintaining water and electrolyte balance for symptomatic and supportive treatment. Comp Neutrophil CD64 and C- reactive protein (CRP) levels in burn sepsis group and control group were compared and neutrophils level and CD64 and C- reactive protein (CRP) level in patients with different burn area. Results In burn sepsis group and control group, neutrophil CD64 and CRP levels were(65.2±18.6)%, (157±34.8)mg/L; (16.8±5.7)%, (19.6±2.2)mg/L, the difference was statistically significant (t=12.4, 13.8, P<0.05). In burn sepsis group (patients with burn area of less than 60%) and burn sepsis patients (burned area greater than 60%), levels of neutrophil CD64 and CRP were( 46.8±13.5)%, (135.7±32.8)mg/L; (76.9±24.3)%, (189.6±40.5)mg/L, the difference was statistically significant (t=8.6, 7.9, P<0.05). In burn sepsis, ROC curve area of neutrophil CD64 (AUC) under the maximum, was better than that of CRP (P<0.05). Using Youden index (the correct index = sensitivity + specificity -1) corresponding to the maximum value; the optimum truncation points meaningful index (cut-off point), draw on the CD64, CRP sensitivity, in the diagnosis of burn sepsis specificity, positive predictive value and negative predictive value; the results showed that the CD64 sensitivity and specificity and the positive predictive value and negative predictive value were higher than those of CRP (P<0.05). Conclusions There is a very high specificity of bacterial infection of CD64 on burn with sepsis;its sensitivity, specificity, positive predictive value, and negative predictive value are higher than CRP.

Key words： burn sepsis C- reactive protein CD64 burn area

Received: 10 October 2014

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	FAN Xia
	HAN Zhongxue
	FU Jinglin

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FAN Xia,HAN Zhongxue,FU Jinglin. Peripheral C-reactive protein and CD64 level dynamic change in patients with burn and sepsis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(4): 387-390.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2015/V26/I4/387

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