血浆尾加压素Ⅱ在慢性阻塞性肺疾病的表达及其意义

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Abstract Objective To observe the expression of plasma urotensinⅡ(UⅡ) in the patients with chronic obstructive pulmonary disease(COPD), and to investigate the implication of UⅡ in the pathogenesis and progress of COPD. Methods Patients with COPD including the acute exacerbated COPD and the stable COPD and the healthy control subjects were recruited, Plasma UⅡ concentration was measured by ELISA. The patients should undergo some exam inations, such as the pulmonary function, complete blood count,bloodgas.SAS6.12 statistical software was used to analyze the data. Results Plasma UⅡ showed a higher expression in acute exacerbated COPD patients than these in stable COPD patients,both highter than in the control subjects and there was statistical significance(P＜0.01).and it was correlated negatively with FEV1.0％,FEV1.0/FVC％,PaO₂. Conclusions The concentration of UⅡ has a trend of increase with the deteriorated change of COPD,and may play an important role in the pathogenic process of COPD,such as hypoxia, airway obstruction and inflammation.

Key words： chronic obstructive pulmonary disease urotensin Ⅱ hypoxia airway obstruction

Received: 07 December 2014

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	SU Xianling
	XIE Lixin

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SU Xianling,XIE Lixin. Expression and implication of plasma urotensin Ⅱ in chronic obstructive pulmonary disease patients[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(5): 444-445.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2015/V26/I5/444

[1]	Droemann D,Albrecht D,Gerdes T,et al.Human lung cancer cells express functionally active Toll-1ike receptor[J].Respirat Rese,2005,6(1):41.
[2]	Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease (revised 2011).(2011-11) [2012-01-02]. http://www.goldcopd.org/guidelines-pocket-guide-to-copd-diagnosis.html.
[3]	张勇刚,陈亚红,马春艳,等.尾加压素的促丝裂作用[J].中国动脉硬化杂志,2001,9(1):14-16.
[4]	孟庆红,赵翠芬,孔清玉,等.尾加压素Ⅱ对大鼠肺动脉平滑肌细胞胶原合成的影响[J].山东大学学报(医学版),2013,51(5):15-19.
[5]	管敏昌,汤卫红,王惠庭,等.尾加压素Ⅱ在哮喘小鼠气道重塑中的表达[J].中国卫生检验杂志,2013,23(8):1912-1914.
[6]	张维溪,梁亚峰,聂颖,等. 布地奈德对哮喘气道重塑大鼠尾加压素Ⅱ及mRNA表达的影响[J].中国药学杂志,2012,47 (6):427-429.
[7]	孙艳宏,孙德俊.氧疗对低氧性肺动脉高压大鼠血浆及肺匀浆中UⅡ的影响[J].中国药学杂志,2011,33(1):427-429.