乙型肝炎前S1、S2抗原与HBV-DNA的相关性分析

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Abstract Objective To study the relationship between HBV Pre-S1 antigen,HBV Pre-S2 antigen and HBV-DNA and investigate the clinical significance of the hepatitis B virus (HBV). Methods The markers Pre-S1 antigen, Pre-S2 antigen were determined by ELISA and HBV-DNA by the fluorescence quantitative PCR in 420 patients with HBV collected from September 2013 to May 2014. HBV, Pre-S1 antigen and Pre-S2 antigen results were analysed in different aspects, such as serum indices, HBV-DNA amounts and HBV-DNA infection types. Results In “big sanyang” patients the positive rates of Pre-S1, S2 antigen and HBV-DNA were 98.48%, 95.45%, 100%,respectively.In “small Sanyang” patients, the positive rates of Pre-S1, S2 antigen and HBV-DNA were 53.25%, 45.45%, 46.75%,respectively.In HBsAg+ HBcAb+ patients the positive rate of Pre-S1, S2 antigen and HBV-DNA were 53.75%, 43.28%, 44.78%,respectively.And the detection rates of HBV Pre-S1 antigen, HBV Pre-S2 antigen were higher in patients infected with high level of HBV-DNA. Conclusions There is a good correlation between HBV Pre-S1 antigen, HBV Pre-S2 antigen and HBV-DNA, which can reflect virus infection and replication.

Key words： Pre-S1Ag Pre-S2Ag HBV-DNA

Received: 23 September 2014

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R512.62

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	HUANG Yanping
	ZHU Feng
	WANG Xinyuan
	ZOU Haolin
	XU Nuo

Cite this article:

HUANG Yanping,ZHU Feng,WANG Xinyuan等. Relationship between hepatitis B virus former S1 antigen,former S2 antigen, and HBV-DNA, and their clinical significance[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(6): 600-602.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2015/V26/I6/600

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