无症状冠心病颈动脉内膜中层厚度与血小板相关指标和超敏C反应蛋白的相关性

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Abstract Objective To study the relationship between carotid intima-media thickness (IMT) and mean platelet volume (MPV), platelet volume distribution width (PDW) and hypersensitive c-reactive protein (Hs-CRP) without clinical manifestation of atherosclerotic cardiovascular disease. Methods Retrospective analysis was performed. We studied the individuals who underwent the color Doppler ultrasound from February to November in 2014. The patients who had known atherosclerotic disease were excluded from study and 85 cases were finally admitted for the study. The patients were divided into IMT high group (55 cases) and IMT normal group (30 cases) according to the median carotid IMT values. A multiple linear regression analysis was performed to identify the independent associations of carotid IMT. Results The IMT high group had higher triglycerides (TG), uric acid (UA), MPV, PDW and Hs-CRP levels than those of the IMT normal group (P<0.05 for all). Multiple linear regression analysis showed that carotid IMT was independently related with MPV (β＝0.215, P<0.001), PDW(β＝-0.039, P=0.037)and Hs-CRP (β=0.258, P=0.001). Conclusions MPV、PDW or Hs-CRP is independently related to the extent of subclinical carotid atherosclerosis respectively. Increase in MPV may be a crucial biochemical marker for initial atherosclerosis.

Key words： carotid intima-media thickness mean platelet volume platelet volume distribution width hypersensitive C-reactive protein atherosclerotic disease

Received: 20 March 2015

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	SHI Genlin
	YAO Liyun
	LIU Hua
	ZHU Feng

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SHI Genlin,YAO Liyun,LIU Hua等. Carotid intima-media thickness is associated with mean platelet volume, platelet volume distribution width and hypersensitive c-reactive protein in patients without clinical manifestation of atherosclerotic cardiovascular disease[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(7): 673-676.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2015/V26/I7/673

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