ADAM33基因V4位点多态性与儿童哮喘易感性的关系

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Abstract Objective To study whether the polymorphisms of V4 in ADAM33 (A Disintegrin and Metalloproteinase 33) gene contribute to the susceptibility to childhood asthma. Methods According to the same criteria, all the clinical studies related to the polymorphism of ADAM33 gene and asthma were searched through PubMed, Ovid-Medline, Embase、CNKI, Wanfang and Weipu databases. All retrieved articles were screened and evaluated followed by meta-analysis using RevMan 5 software. Results Six studies were included based on the selection criteria. In these studies, 1435 childhood asthma and 1710 controls were identified and all control group genotype frequencies were consistent with Hardy-Weinberg equilibrium. By meta-analysis, in allele and dominant models and recessive models,ADAM33 gene V4 polymorphism was not related to liability of childhood asthma (G与C:OR=1.33,95%CI=0.96-1.84,P=0.09;CG+GG与CC:OR=1.41,95%CI=0.95-2.08,P=0.09;CC+CG与GG:OR=0.47,95%CI=0.18-1.22,P=0.12). Conclusion Polymorphism of ADAM33 V4 seems not to be involved in elevated risk of childhood asthma.

Key words： childhood asthma ADAM33 genetic polymorphism Meta-analysis

Received: 31 August 2015

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	Articles by authors
	LI Xin
	LI Hongbin
	JIN Yan
	and HAO Donglan

Cite this article:

LI Xin,LI Hongbin,JIN Yan等. Association between ADAM33 V4 polymorphsim and susceptibility in childhood asthma: a meta-analysis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(11): 1134-1136.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2015/V26/I11/1134

[14]	Chi X, Wang L, Wang J,et al. Association of ADAM33 gene polymorphisms with asthma in a Chinese population [J]. Clin Respir J, 2013, 7(1): 16-20.
[1]	Zhang Y, Zhang J, Huang J,et al. Polymorphisms in the transforming growth factor-beta1 gene and the risk of asthma: A meta-analysis [J]. Respirology, 2010, 15(5): 643-650.
[15]	Tripathi P, Awasthi S, Prasad R,et al. Association of ADAM33 gene polymorphisms with adult-onset asthma and its severity in an Indian adult population [J]. J Genet, 2011, 90(2): 265-273.
[2]	Van Eerdewegh P, Little R D, Dupuis J,et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness[J]. Nature,2002, 418(6896): 426-430.
[3]	de Faria I C, de Faria E J, Toro A A,et al. Association of TGF-beta1, CD14, IL-4, IL-4R and ADAM33gene polymorphisms with asthma severity in children and adolescents[J]. J Pediatr (Rio J), 2008, 84(3): 203-210.
[16]	Su D, Zhang X, Sui H,et al. Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population [J]. BMC Med Genet,2008, 9(9):82-87.
[4]	Bateman E D, Hurd S S, Barnes P J,et al. Global strategy for asthma management and prevention: GINA executive summary [J]. Eur Respir J, 2008, 31(1): 143-178.
[17]	Thongngarm T, Jameekornrak A, Limwongse C,et al. Association between ADAM33 polymorphisms and asthma in a Thai population [J]. Asian Pac J Allergy Immunol, 2008, 26(4): 205-211.
[5]	Collaborative Study on the Genetics of Asthma. A genome-wide search for asthma susceptibility loci in ethnically diverse populations [J]. Nat Genet, 1997, 15(4): 389-392.
[6]	DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials: an update [J]. Contemp Clin Trials, 2007, 28(2): 105-114.
[7]	Zihlif M, Zihlif N, Obeidat N M,et al. Association between ADAM33 polymorphisms and Susceptibility with adult and childhood asthma among Jordanians [J]. Genetic Testing and Molecular Biomarkers,2014,18(11): 767-774.
[8]	Godava M, Kopriva F, Bohmova J,et al. Association of STAT6 and ADAM33 single nucleotide polymorphisms with asthma bronchiale and IgE level and its possible epigenetic background [J]. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2012, 156(3): 236-247.
[9]	Qu S, Sun D, Wang Y,et al. Association of ADAM33 polymorphisms with childhood asthma in a northern Chinese population [J]. Exp Mol Pathol, 2011, 91(3):775-779.
[10]	Awasthi S, Tripathi P, Ganesh S, et al. Association of ADAM33 gene polymorphisms with asthma in Indian children [J]. J Human Genetics, 2011, 56(3): 188-195.
[11]	Matsusue A, Kiyohara C, Tanaka, et al. KADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children [J]. Clinical Biochemistry, 2009, 42(6): 477-483.
[12]	Schedel M, Depner M, Schoen C,et al. The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations [J]. Respir Res, 2006, 19 (7): 91-102.
[13]	Umland S P, Garlisi C G, Shah H,et al. Human ADAM33 messenger RNA expression profile and post-transcriptional regulation [J]. Am J Respir Cell Mol Biol, 2003, 29(5): 571-582.
[14]	Chi X, Wang L, Wang J,et al. Association of ADAM33 gene polymorphisms with asthma in a Chinese population [J]. Clin Respir J, 2013, 7(1): 16-20.
[15]	Tripathi P, Awasthi S, Prasad R,et al. Association of ADAM33 gene polymorphisms with adult-onset asthma and its severity in an Indian adult population [J]. J Genet, 2011, 90(2): 265-273.
[16]	Su D, Zhang X, Sui H,et al. Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population [J]. BMC Med Genet,2008, 9(9):82-87.
[17]	Thongngarm T, Jameekornrak A, Limwongse C,et al. Association between ADAM33 polymorphisms and asthma in a Thai population [J]. Asian Pac J Allergy Immunol, 2008, 26(4): 205-211.

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