重症肺炎呼吸衰竭患者使用无创呼吸机的通气状况及其改善效果

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Abstract Objective To study the improving effect of non-invasive ventilation on ventilation condition and clinical symptoms in patients with respiratory failure caused by severe pneumonia. Methods 50 patients with respiratory failure caused by severe pneumonia in this hospital were randomly divided into study group and control group. Study group received noninvasive positive pressure ventilation, whereas control group received nasal oxygen catheterization. Then, ventilation condition, cardiac function index, serum inflammatory mediators amd adverse reactions were compared between the two groups. Results Ventilation index: in the study group PaO₂(82.32±9.34)mmHg, SaO₂(95.52±9.19)% was significantly higher than in the control group, (70.29±7.78)mmHg, SaO₂(90.01±9.04)%; PaCO₂ was significantly lower than in the control group(t=2.150-6.161, P<0.05). Cardiac function index: in the study group RR, HR, LVEDD were significantly lower than in the control group, LVEF was significantly higher than in the control group(t=3.284-5.022, P<0.05). Inflammation medium content: in the study group, TNF-α, IL-6, IL-1β were significantly lower than in the control group(t=11.928-19.9444, P<0.05). Adverse reactions: in the study group adverse reactions rate was 40.00%, significantly lower than 68.00% in the control group. Conclusions Noninvasive positive pressure ventilation improves ventilation condition and clinical symptoms, and relieves inflammation.

Key words： severe pneumonia respiratory failure noninvasive positive pressure ventilation inflammatory mediators

Received: 30 August 2015

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	Articles by authors
	XIE Huanyin
	CHEN Haiying
	ZHANG Jianzhong
	ZHANG Yinjun
	and SUN Hongjuan

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XIE Huanyin,CHEN Haiying,ZHANG Jianzhong等. Improving effect of non-invasive ventilation on ventilation condition and clinical symptoms in patients with respiratory failure caused by severe pneumonia[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(12): 1245-1247.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2015/V26/I12/1245

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