经骨髓间充质干细胞诱导分化的神经样细胞对大鼠脊髓损伤的修复作用

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Abstract Objective To study transplantation of bone mesenchymal stem cells (BMSCs) derived neuron-like cells for repairing the rat spinal cord injury. Methods BMSCs were isolated from the femur of 4-week-old Sprague-Dawley rats, after culture and proliferation, then differentiated into neuron-like cells induced by retinoic acid (RA). After spinal cord injury (SCI) model preparation, forty-eight rats were randomly assigned to the following three groups (n=18): the neuron-like cells group, the BMSCs group and the control group. The rats’ motor functional recovery was evaluated by BBB score and Rivlin platform test at 2 w, 4 w, 6 w after operation. Results The neuron-like cells derived from BMSCs had some neurocyte characteristics. Transplantation of neuron-like cells(16.56±2.42) showed higher score than BMSCs(13.70±2.66). The rat functional recovery in the neuron-like cells group and the BMSCs group was better than in the control group. There was more nerve fibers with normal structure could be observed in the neuron-like cells group. Conclusions Transplantation of neuron-like cells derived from BMSCs for treating rat spinal cord injury is a promising treatment.

Key words： BMSCs neuron-like cells differentiation spinal cord injury

Received: 20 June 2015

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	Articles by authors
	GAO Feng
	ZHANG Xiaofeng
	DUAN Yanwei
	YAN Huaining
	PAN Yongfei
	YE Rong
	and WEN Li

Cite this article:

GAO Feng,ZHANG Xiaofeng,DUAN Yanwei等. Transplantation of bone mesenchymal stem cells derived neuron-like cells for treatment of rat spinal cord injury[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(3): 285-288.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2016/V27/I3/285

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