萘哌地尔治疗输尿管远端结石有效性和安全性的Meta分析

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Abstract Objective To access the efficacy and safety of naftopidil in medical expulsive therapy of distal ureteral calculi. Methods A systematic search was performed in Pubmed, Cochrane Library, CNKI, Wanfang database and VIP database to identify RCTs that compared naftopidil and other therapy for distal ureteral calculi. Two authors independently assessed study quality and extracted data. All data were analyzed using RevMan5.0. Results 11 studies with a total of 983 patients met the inclusion criteria. There was a significant overall benefit for stone expulsion rate(RR=1.63, 95%CI 1.32-2.03, P＜0.01)and stone expulsion time(WMD=-2.83, 95% CI -3.75--1.92, P＜ 0.01)in naftopidil group compared with watching waiting group. Compared with α_1A adrenergic receptor blockers group, there was no statistically significant differences in expulsion rate(RR=0.97, 95% CI 0.78-1.20, P=0.76)and stone expulsion time(WMD=0.15, 95%CI -0.40-0.69, P=0.59). But naftopidil provided a significantly lower side effects rate(RR=0.52, 95%CI 0.27-0.98, P=0.04). Conclusions Naftopidil can effectively promote the expulsion of distal ureteral calculi. Compared with α_1A-adrenergic receptor blockers, there are no statistically significant differences in expulsion rate and stone expulsion time, but with a significantly lower side effects rate.

Key words： distal ureteral calculi naftopidil α_1D adrenergic receptor blockers medical expulsive therapy Meta-analysis

Received: 20 April 2016

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	Articles by authors
	GAO Hao
	NING Songyi
	LIU Guang
	HU Yougen
	and TANG Yuanjie

Cite this article:

GAO Hao,NING Songyi,LIU Guang等. Efficacy and safety of naftopidil for treatment of distal ureteral calculi: a systematic review and meta-analysis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(9): 895-899.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2016/V27/I9/895

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