2型糖尿病肌钙蛋白Ⅰ升高的预测因素及预后价值

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Abstract Objective To find out about the prevalence, determinants, and prognostic implications of cardiac troponin I (cTnI) elevations in patients with Type 2 diabetes mellitus (T2DM). Methods scTnI was measured in stored, frozen serum samples from 552 subjects with T2DM enrolled in our hospital at baseline. Results were analyzed in relation to baseline characteristics and conventional cardiovascular risk factors. All these patients were followed up for 2 years for any incidence of MACE, including heart failure (HF), myocardial infarction (MI) and cardiovascular mortality. Results 90.0 % of these patients had detectable cTnI at baseline and 70 of them (12.7 % of the total) had values above the 99th percentile for healthy controls. Levels at baseline were associated with concomitant CAD (OR: 2.93, 95% CI: 1.33-6.44, P<0.01) and lower eGFR (OR: 0.97, 95% CI: 0.95-0.99, P=0.02). A total of 43 cases of MACE occurred, including HF (n=18), MI (n=11) and cardiovascular mortality (n=14). Multivariate analysis also revealed that an elevated cTnI was an independent predictor of MACE (HR: 2.86, 95% CI: 1.16-7.04, P=0.02) and HF (HR: 3.87, 95% CI: 1.22-15.19, P=0.03). Conclusions Elevations of cTnI above the 99th percentile were frequent in T2DM patients. cTnI levels appear to be associated with concomitant CAD and lower eGFR. Also, elevated cTnI in patients with T2DM is associated with increased risks of MACE.

Key words： type 2 diabetes mellitus troponin I determinants prognostic value

Received: 12 June 2016

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	Articles by authors
	TIAN Donghua
	WANG Yonghong
	and LI Mengbo

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TIAN Donghua,WANG Yonghong,and LI Mengbo. Determinants and prognostic value of troponin-I for adverse outcomes in patients with type 2 diabetes mellitus[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(11): 1117-1120.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2016/V27/I11/1117

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