高压氧对阿尔茨海默病模型小鼠认知功能的影响

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Abstract Objective To investigate the effect of hyperbaric oxygen on cognitive functions of mice with Alzheimer’s and related mechanisms in order to contribute to the treatment of Alzheimer’s disease.Methods 36 KM mice were randomly divided into three groups: normal control group, dementia model group, and hyperbaric oxygen treatment group. D-galactose(120 mg/kg)and sodium nitrite (90 mg/kg)were used to establish a mouse model of Alzheimer’s. The cognitive functions of mice were determined by Morris water maze, the mice’s hippocampus SOD and GSH-Px activity. The MDA level was also determined.Results Compared with the normal control group, the escape latency of the dementia model mice were prolonged, but the times of spanning the platform were significantly reduced (P<0.01). After hyperbaric oxygen treatment, escape latency was shortened while the times of spanning the platform increased. The difference was of statistical significance (P<0.01). Compared with the control group, the hippocampus SOD and GSH-Px activity in dementia model group were significantly reduced, but the MDA level was significantly increased (P<0.01). Afterhyperbaric oxygen treatment, the hippocampus SOD and GSH-Px activity of dementia model mice were significantly increased while the MDA level was significantly reduced. There were significant differences (P<0.01).Conclusions Hyperbaric oxygen therapy can improve cognitive functions in mice with Alzheimer’s, which is possibly because hyperbaric oxygen can significantly improve the body’s ability to combat free radical damage.

Key words： hyperbaric oxygen Alzheimer disease cognitive function oxidative stress

Received: 15 July 2016

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	Articles by authors
	LV Yuxia
	LI Hui
	YAN Fuqin
	RAN Min
	and LI Yan

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LV Yuxia,LI Hui,YAN Fuqin等. Effects of hyperbaric oxygen on cognitive function in mice with Alzheimer’s[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(11): 1126-1128.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2016/V27/I11/1126

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