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The effect of tripterygium hypoglaucum hutch combined with hydrochlorothiazide in the treatment of Graves’ ophthalmopathy |
DUAN Jiyuan, SHAO Bin, and QIAO Yanyan |
Armymen’s Wards,Shanxi Provincial Corps Hospital, Chinese People’s Armed Police Forces, Xi’an 710054, China |
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Abstract Objective To study the effect of tripterygium hypoglaucum hutch combined with hydrochlorothiazide in the treatment of Graves’ ophthalmopathy.Methods 122 patients with Graves’ ophthalmopathy,whose thyroid function had returned to normal and who were taking a maintenance dose of methimazole, were randomly and equally divided into 3 groups. Group A was given routine treatment, group B was given routine treatment plus tripterygium hypoglaucum hutch, and group C was given routine treatment plus tripterygium hypoglaucum hutch and hydrochlorothiazide. The therapeutic effect was analyzed after 3 months.Results The effective rate was 40%(16/40)in group A,70.7%(29/41)in group B,and 85.3%(35/41)in group C. Group B and C were significantly different from group A(P<0.05),while group B was significantly different from group C(P<0.05).Conclusions The combination treatment of tripterygium hypoglaucum hutch and hydrochlorothiazide can improve symptoms of Graves’ ophthalmopathy. So this approach can be used for treating Graves’ ophthalmopathy.
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Received: 07 June 2016
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[1] |
Hahn E,Laperriere N,Millar B A,et al. Orbital radiation therapy for Graves’ ophthalmopathy: measuring clinical efficacy and impact[J]. Pract Radiat Oncol,2014, 8(4): 233-239.
|
[2] |
葛均波,徐永健.内科学[M].8版.北京: 人民卫生出版社,2013:685-692.
|
[3] |
Jiang X,Huang X C,Ao L, et al. Total alkaloids of Tripterygium hypoglaucum(levl.) Hutch inhibits tumor growth both in vitro and in vivo [J]. J ethnopharmacol,2014,151(1):292-298.
|
[4] |
谢晨琼,周 萍,李 祥.昆明山海棠化学成分及药理作用和临床应用研究进展[J].中草药,2015,46(13): 1996-1998.
|
[5] |
王 芳,张 瑜,赵余庆. 昆明山海棠的化学成分研究[J].中草药,2011,42(1): 46-49.
|
[6] |
李艳平.几种常见利尿、脱水药的使用方法及不良反应[J].临床合理用药,2012,58(5): 74-75.
|
[7] |
藤强丰.昆明山海棠联合抗甲状腺药物及泼尼松治疗甲亢相关性眼病疗效分析[J].广西医科大学学报,2013,30(4): 602-603.
|
[8] |
薛洪霞.昆明山海棠片治疗甲状腺功能亢进症30例疗效观察[J].河北中医,2012,34(7):1051-1052.
|
[9] |
汤 勇.昆明山海棠免疫抑制剂机理研究进展[J].云南医药,2005,26(3):289-291.
|
[10] |
Xu Y,Zheng Y T,He L,et al.Study of Tripterygium hypoglaucum Hutch on mouse’s splenic lymphocyte activation in vitro [J]. Zhong Yao Cai,2008,31(4):557-561.
|
[1] |
. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(7): 626-628. |
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