FOXP1与Livin基因表达对淋巴瘤病理特征及临床预后评价价值

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (675 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the significance of FOXP1 and Livin expressions in the evaluation of clinicopathological characteristics and prognosis of lymphoma.Methods Eighty patients with diffuse large B cell lymphoma treated at our hospital between August 2013 and August 2015 were selected as observation group, with 40 cases of reactive lymph node hyperplasia patients as control group. The expressions of FOXP1 and Livin in the two groups were observed and analyzed. The relationships between the expressions of FOXP1 and Livin in patients with lymphoma and the clinicopathological features were analyzed.Results The percentage of high expressions of FOXP1 and Livin in the observation group was 77.5% and 60% respectively, which was significantly higher than that in the control group (20%, 5%), and the difference was statistically significant (P<0.05). Among the high-risk IPI and non-GCB patients of lymphoma or those with primary lymphoma, high expression rates of FOXP1 were 92.3%, 86.2%, 86.7% respectively, the proportion was higher, and the difference was statistically significant (P<0.05). In the presence of B-symptom, the expression rates of Livin were 81.2%, 80.8%, 73.3% respectively, the proportion was higher, and the difference was of statistic significance (P<0.05).Conclusions The expression level of FOXP1 and Livin in patients with diffuse large B cell lymphoma is closely related to its clinical features and pathological types.

Key words： lymphoma B cell prognosis tumor marker

Received: 23 May 2016

ZTFLH:

R365

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2016/V27/I12/1237

[1]	陈敏,杨桂芳.弥漫大B细胞淋巴瘤两种亚型中多药耐药蛋白的表达差异及临床意义[J].武汉大学学报(医学版),2016,37(2):232-235.
[2]	Chuan He, Zhigang Liu, Jie Ji,et al. Prognostic value of survivin in patients with non-Hodgkin’s lymphoma: a meta-analysis[J].Int J Clin Exp Med,2015,8(4): 5847-5854.
[3]	齐彦,廖斌,杨丽英,等.非霍奇金淋巴瘤中MCM2、Cx43、Skp2蛋白的表达[J].现代肿瘤医学,2016,24(6):958-961.
[4]	Bo-Young Oh, Ryung-Ah Lee, Kwang Ho Kim. siRNA targeting Livin decreases tumor in a xenograft model for colon cancer[J].World J Gastroenterol,2011,17(20): 2563-2571.
[5]	王健超,张文燕,丁文双,等.异常表达CD56的弥漫性大B细胞淋巴瘤临床病理观察[J].中华病理学杂志,2016,10(2):78-82.
[6]	范小红,孟亚红,邹健等.乙肝表面抗原阳性的非霍奇金淋巴瘤患者化疗前后T淋巴细胞亚群的变化[J].现代中西医结合杂志,2016,25(9):920-922.
[7]	李贻阳,牛绍清,温戈,等.基于GELOX方案诱导化疗的Ⅰ-Ⅱ期结外鼻型K／T细胞淋巴瘤根治性放疗的预后分析[J].中华放射肿瘤学杂志,2016,25(2):140-145.
[8]	张亚楠.FOXP1蛋白在弥漫性大B细胞淋巴瘤中的表达及预后意义[J].重庆医学,2015,44(17):2368-2370.
[9]	朱丹,王瑛坚.原发性卵巢上皮性恶性肿瘤中Livin和Fas的表达及相关性分析[J].中国实验诊断学,2014,18(8):1312-1314.
[10]	陈廷玉,卢春凤,关宝生,等.宫颈癌中Livin和COX-2蛋白的表达及相关性研究[J].解剖学研究,2015,37(5):398-400.
[11]	胡成如,王靖华,耿怀成,等.叉头框转录蛋白1在弥漫性大B细胞淋巴瘤中的表达及预后意义[J].临床肿瘤学杂志,2012,17(4):339-342.
[12]	沈琳,陈波斌,陈字,等.原发性中枢神经系统淋巴瘤FOXPl和CyclinE的表达及其意义[J].中华血液学杂志,2012,33(8):648-652.
[13]	I Abd-Elrahman, V Deutsch, M Pick, et al. Differential regulation of the apoptotic machinery during megakaryocyte differentiation and platelet production by inhibitor of apoptosis protein Livin[J].Cell Death Dis,2013,4(11): e937.
[14]	李蓉,潘湘涛,陆晔,等.Livin和Smac蛋白在非霍奇金淋巴瘤中的表达及其临床意义[J].白血病.淋巴瘤,2010,11(8):494-496.
[15]	李文琦,李晓林.Livin和Survivin基因在成人急性淋巴细胞白血病中的表达及临床意义[J].中国实验血液学杂志,2011,19(4):921-925.