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| Non-conjunctival primary ocular adnexal mucosa associated lymphoid tissue lymphoma(POAML) treated with primary radiotherapy |
| ZHAO Shuixi1, YU Liquan1, BU Jie1, CAO Jingxu1, and XIAO Lihua2 |
| 1.Department One of Oncology, 2.Institute of Orbital Disease, General Hospital of Chinese People’s Armed Police Force,Beijing 100039,China |
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Abstract Objective To evaluate the dose response of patients with ⅠE stage non-conjunctival primary ocular adnexal mucosa associated lymphoid tissue lymphoma(POAML) treated with primary radiotherapy.Methods Clinical data on thirty-three patients(42 eyes) with stage Ⅰnon-conjunctival POAML treated between November 2003 and Match 2012 were retrospectively studied.Results For all the patients, the local control rate was 100% at the dose of 18 Gy and 27 Gy, while the response rate was 31% and42.9%(P=0.258)respectively as measured with the WHO criteria. However, the response rate was 28.6% and38.1%(P=0.355)respectively as measured with the RECIST criteria. For patients of non-conjunctival POAML treated at the dose of ≥30.6 Gy and 27 Gy, the five-year overall survival(OS) rate was 100% and 95.7% respectively (P=0.8578), and the five-year progression-free survival(PFS) rate was 83.3% and 91.1% respectively (P=0.6497).Conclusions The prescribed dose of 27 Gy for non-conjunctival POAML seems to be effective. Prospective clinical studies should be carried out to define the optimal dose for POAML.
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Received: 22 July 2016
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| [1] |
Lazzarino M, Morra E, Rosso R, et al. Clinicopathologic and immunologic characteristics of non Hodgkin’s lymphoma presenting in the orbit[J]. Cancer,1985,55(9):1907-1912.
|
| [2] |
Bairey O, Kremer I, Rakowsky E, et al. Orbital and adnexal involvement in systemic non-Hodgkin’s lymphoma[J]. Cancer,1994,73(9):2395-2399.
|
| [3] |
Freeman C, Berg J W, Cutler S J. Occurrence and prognosis of extranodal lymphomas[J]. Cancer,1972,29(1):252-260.
|
| [4] |
White W L,Ferry J A,Harris N L,et al.Ocular adnexal lymphoma: a clinicopathologic study with identi cation of lymphomas of mucosa-associated lymphoid tissue type[J].Ophthalmology,1995,102(12):1994-2006.
|
| [5] |
McKelvie P A, McNab A, Francis I C, et al. Ocular adnexal lymphoproliferative disease: a series of 73 cases[J].Clin Experiment Ophthalmol,2001,29(6):387-393.
|
| [6] |
Meunier J, Lumbroso-Le Rouic L, et al. Ophthalmologic and intraocular non-Hodgkin’s lymphoma: a large single centre study of initial characteristics, natural history, and prognostic factors[J]. Hematol Oncol,2004,22(4):143-158.
|
| [7] |
Ferry J A, Fung C Y, Zukerberg L, et al. Lymphoma of the ocular adnexa: a study of 353 cases[J]. Am J Surg Pathol,2007,31(2):170-184.
|
| [8] |
Nakata M, Matsuno Y, Katsumata N, et al. Histology according to the Revised European-American Lymphoma Classification significantly predicts the prognosis of ocular adnexal lymphoma[J]. Leuk Lymphoma,1999,32(5-6):533-543.
|
| [9] |
Mannami T,Yoshino T, Oshima K, et al. Clinical, histopathological, and immunogenetic analysis of ocular adnexal lymphoproliferative disorders: characterization of MALT lymphoma and reactive lymphoid hyperplasia[J]. Mod Pathol,2001,14(7):641-649.
|
| [10] |
Cho E Y, Han J J, Ree H J, et al. Clinicopathologic analysis of ocular adnexal lymphomas: extranodal marginal zone B-cell lymphoma constitutes the vast majority of ocular lymphomas among Koreans and affects younger patients[J]. Am J Hematol,2003,73(2):87-96.
|
| [11] |
Lee J L, Kim M K, Lee K H, et al. Extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue type of the orbit and ocular adnexa[J]. Ann Hematol, 2005,84(1):13-18.
|
| [12] |
Woo J M, Tang C K, Rho M S, et al. The clinical characteristics and treatment results of ocular adnexal lymphoma[J]. Korean J Ophthalmol,2006,20(1):7-12.
|
| [13] |
Yoon J S,Ma K T,Kim S J,et al.Prognosis for patients in a Korean population with ocular adnexal lymphoproliferative lesions[J].Ophthal Plast Reconstr Surg,2007,23(2):94-99.
|
| [14] |
Le Q T, Eulau S M, George T I, et al. Primary radiotherapy for localized orbital MALT lymphoma[J]. Int J Radiat Oncol Biol Phys,2002,52(3): 657-663.
|
| [15] |
Tsang R W, Gospodarowicz M K, Pintilie M, et al. Localized mucosa-associated lymphoid tissue lymphoma treated with radiation therapy has excellent clinical outcome[J]. J Clin Oncol,2003,21(22):4157-4164.
|
| [16] |
Fung C Y, Tarbell N J, Lucarelli M J, et al. Ocular adnexal lymphoma: clinical behavior of distinct world health organization classification subtypes[J]. Int J Radiat Oncol Biol Phys,2003,57(5): 1382-1391.
|
| [17] |
Hasegawa M, Kojima M, Shioya M, et al. Treatment results of radiotherapy for malignant lymphoma of the orbit and histopathological review according to the WHO classification[J]. Int J Radiat Oncol Biol Phys,2003,57(1):172-176.
|
| [18] |
Uno T, Isobe K, Shikama N, et al. Radiotherapy for extranodal, marginal zone, B-cell lymphoma of mucosa-associated lymphoid tissue originating in the ocular adnexa. A multiinstitutional, retrospective review of 50 patients[J]. Cancer,2003,98(4):865-871.
|
| [19] |
Lee J L, Kim M K, Lee K H, et al. Extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue-type of the orbit and ocular adnexa[J]. Ann Hematol,2005,84(1):13-18.
|
| [20] |
Aviles A, Neri N, Calva A, et al. Addition of a short course of chemotherapy did not improve outcome in patients with localized marginal B-cell lymphoma of the orbit[J]. Oncology,2006,70(3):173-176.
|
| [21] |
Suh C O, Shim S J, Lee S W, et al. Orbital marginal zone B-cell lymphoma of MALT: radiotherapy results and clinical behavior[J]. Int J Radiat Oncol Biol Phys, 2006,65(1):228-233.
|
| [22] |
Ejima Y,Sasaki R,Okamoto Y,et al.Ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy[J].Radiother Oncol,2006,78(1):6-9.
|
| [23] |
Yamashita H,Nakagawa K,Asari T,et al.Radiotherapy for 41 patients with stages I and II MALT lymphoma: a retrospective study[J].Radiother Oncol,2008,87(3):412-417.
|
| [24] |
Nam H,Ahn Y C,Kim Y D,et al.Prognostic significance of anatomic subsites:results of radiation therapy for 66 patients with localized orbital marginal zone B cell lymphoma[J].Radiother Oncol,2009,90(2):236-241.
|
| [25] |
Son S H, Choi B O, Kim G W, et al. Primary radiation therapy in patients with localized orbital marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) [J]. Int J Radiat Oncol Biol Phys,2010,77(1):86-91.
|
| [26] |
Hata M, Omura M, Koike I, et al. Treatment effects and sequelae of radiation therapy for orbital mucosa-associated lymphoid tissue lymphoma[J]. Int J Radiat Oncol Biol Phys, 2011,81(5):1387-1393.
|
| [27] |
Goda J S, Le L W, Lapperriere N J, et al. Localized orbital mucosa-associated lymphoma tissue lymphoma managed with primary radiation therapy: efficacy and toxicity[J]. Int J Radiat Oncol Biol Phys,2011,81(4):e659-666.
|
| [28] |
Hashimoto N, Sasaki R, Nishimura H, et al. Long-term outcome and patterns of failure in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy[J]. Int J Radiat Oncol Biol Phys,2012,82(5): 1509-1514.
|
| [29] |
Ohja S, Nakamura K, Shioyama Y, et al. Treatment outcome of radiotherapy for localized primary ocular adnexal MALT lymphoma-prognostic effect of the AJCC Tumor-Node-Metastasis clinical staging system[J].Anticancer Res,2015,35(6):3591-3597.
|
| [30] |
Jung S K, Paik J S, Jung S E, et al. Suggestion of response evaluation criteria in patients with ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML) [J]. Ann Hematol,2015,94(7):1185-1193
|
| [31] |
Gayed I, Eskandari M F, McLaughlin P, et al. Value of positron emission tomography in staging ocular adnexal lymphomas and evaluating their response to therapy[J]. Ophthalmic Surg Lasers Imaging,2007,38(4):319-325.
|
| [32] |
Harada K, Murakami N, Kitaguchi M, et al. Localized ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiation therapy: a long-term outcome in 86 patients with 104 treated eyes[J]. Int J Radiat Oncol Biol Phys,2014,88(3):650-654.
|
| [1] |
. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(1): 1-4. |
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2016, Vol. 27 
