两种方式吸入布地奈德联合异丙托溴铵治疗急性感染性喉炎效果比较

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Abstract Objective To compare the curative efficacy of budesonide in combination with ipratropium bromide administrated by air compression atomizing inhalation and ultrasonic atomizing inhalation respectively in patients with acute infectious laryngitis and its effects on interleukin-4 (IL-4) and immunoglobulin E (IgE).Methods 120 patients with acute infectious laryngitis who received therapy in our hospital from January 2015 to June 2016 were selected as subjects. According to the random number table, those patients were randomly divided into the control group (n=60) and the observation group (n=60). Besides conventional treatments, all patients were treated with budesonide in combination with ipratropium bromide administrated by atomizing inhalation. The control group was given air compression atomizing inhalation, while the observation group was given ultrasonic atomizing inhalation. Then, the curative efficacy, time taken by improvement of clinic symptoms and levels of serum IL-4, IgE were compared between the two groups.Results The total therapeutic efficacy rate in the observation group was statistically higher than that in the control group (95.0% vs 83.3%, P<0.05). In comparison with the control group, the time taken by improvement of cough, hoarseness and laryngeal stridor in the observation group was statistically shorter respectively [(3.3±0.8) d vs (4.2±1.0) d, (3.5±0.6)d vs (4.3±1.2) d, (6.4±0.9)d vs (7.9±1.4) d, all P<0.05)]. After the treatment, levels of serum IL-4 and IgE in the observation group were statistically lower than those in the control group [(7.24±1.83) ng/L vs (15.19±2.36) ng/L, (50.43±9.62) μg/L vs (82.25±10.45) μg/L, both P<0.05)].Conclusions For patients with acute infectious laryngitis, ,ultrasonic atomizing inhalation has not only a higher total therapeutic efficacy rate, shorter improvement time of clinic symptoms and lower levels of IL-4, IgE than budesonide in combination with ipratropium bromide administrated by air compression atomizing inhalation, but also some other advantages.

Key words： air compression atomizing inhalation ultrasonic atomizing inhalation budesonide ipratropium bromide acute infectious laryngitis interleukin-4 immunoglobulin E

Received: 02 November 2016

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	Articles by authors
	XIAO Jingjing
	NONG Hua
	HAN Lin
	and ZHANG Jianmei

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XIAO Jingjing,NONG Hua,HAN Lin等. Comparison of clinical efficacy of air compression atomizing inhalation and ultrasonic atomizing inhalation with budesonide combined with ipratropium bromide for patients with acute infectious laryngitis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(2): 143-145.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2017/V28/I2/143

[1]	Jolliffe D A, Griffiths C J, Martineau A R.Vitamin D in the prevention of acute respiratory infection: systemic review of clinical studies[J].J Steroid Biochem,2013(136):321-329.
[2]	施弦.布地奈德联合干扰素雾化吸入治疗小儿急性感染性喉炎疗效分析[J].浙江中医药大学学报,2012,36(5):529-531.
[3]	王陈裕,华刚,楼寿增,等.3%高渗盐水联合复方异丙托溴铵治疗幼儿毛细支气管炎的临床研究[J].中国临床药理学杂志,2014,30(2):122-124.
[4]	King S, Glanville J, Sanders M E, et al. Effectiveness of probiotics on the duration of illness in healthy children and adults who develop common acute respiratory infectious conditions: a systemic review and meta-analysis[J]. Brit J Nutr,2014,112(1):41-54.
[5]	周少宏,王君霞,戴永利.布地奈德混悬液雾化吸入在儿童急性喉炎、喉气管支气管炎中的疗效观察[J].中国急救复苏与灾难医学杂志,2014,9(6):503-505.
[6]	Ninbovorl J,Sawatdee S,Srichana T.Factors affecting the stability and performance of ipratropium bromide; fenoterol hydrobromide pressurized-metered dose inhalers[J]. AAPS Pharm Sci Tech,2013,14(4): 1294-1302.
[7]	赵明德.布地奈德雾化吸入治疗小儿轻度急性感染性喉炎的临床疗效观察[J].儿科药学杂志,2012,18(7):26-28.
[8]	周艳梅,李清,张有为,等.氨溴索联合利巴韦林经空气压缩泵雾化吸入治疗细支气管炎疗效观察[J].中国全科医学,2011,14(32):3751-3752.
[9]	魏晓萍.喉腔滴药和超声雾化加音频治疗306例慢性喉炎的疗效观察[J].重庆医学,2011,40(1):75-76.
[10]	Joo Y H, Lee S S, Han K D, et al. Association between chronic laryngitis and particulate matter base on the korea national health and nutrition examination survey 2008-2012[J]. Plos One,2015,10(7):78-79.
[11]	薛国昌,任明星,周静月,等.感染性喉炎和痉挛性喉炎患儿血清中IL-4、IFN-γ和IgE水平检测的临床意义[J].新医学,2014,45(1):49-52.
[12]	任明星,薛国昌,周静月,等.痉挛性喉炎患儿血清白细胞介素-4、γ干扰素和免疫球蛋白E水平变化的意义[J].中华实用儿科临床杂志,2014,29(4):286-288.
[13]	李晓娜,李玉杰,黄炜,等.布地奈德对小儿感染性喉炎的疗效及IL-4、IFN-γ和IgE水平的影响[J].中国妇幼保健,2015,30(30):5194-5196.