3种益生菌制剂联合美沙拉秦口服治疗轻中度溃疡性结肠炎疗效

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Abstract Objective To observe the therapeutic effect of Bifidobacterium tetravaccine Tablets(live), Clostridium butyricum powder, Saccharomyces boulardii sachets combined with Mesalazine SR granules on mild or moderate ulcerative colitis.Methods A total of 160 patients who had been treated between January 2014 and December 2016 were randomly divided into the trail group and three control groups(40 patients in each group). Each of the control groups took two types of probiotic agents (not the same type between the three control groups) and Mesalazine SR granules, while the trail group took the three types of probiotic agents and Mesalazine SR granules. The therapy lasted 4 weeks. Mayo activity index scores, fecal calprotectin values, colonoscopy scores, gastrointestinal quality of life indexes and clinical effect were compared between the trail group and control group.Results After treatment, the Mayo activity index score in the trail group was reduced to 1.43±; 0.86, fecal calprotectin value to 135.33±; 95.53, colonoscopy score to 2.17±; 1.21, while the gastrointestinal quality of life index was elevated to 114.33±; 13.51. There was statistically significant difference (P<; 0.05) between the trail group and each control group in the above indicators. The changes were also statistically significant after treatment in each group (P<; 0.05), but there was not statistically significant difference between the control groups. There was some correlation between the Mayo score and fecal calprotectin levels.Conclusions Bifidobacterium tetravaccine Tablets(live), Clostridium butyricum powder, Saccharomyces boulardii sachets combined with Mesalazine SR granules are effective and safe for mild or moderate ulcerative colitis.

Key words： probiotic ulcerative colitis fecal calprotectin

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R574.62

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	BO Maolin
	XUE Zhilan
	ZHANG Tao.

Cite this article:

BO Maolin,XUE Zhilan,ZHANG Tao.. Clinical effect of three probiotic agents combined with Mesalazine in treatment of mild or moderate ulcerative colitis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(10): 980-984.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2017/V28/I10/980

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