儿童肾母细胞瘤肺转移临床特点及其相关因素

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Abstract Objective To investigate the risk factors of pulmonary metastases in children with stage Ⅳ Wilms tumor (WT) in order to provide data for the assessment of prognosis and guide clinical treatment and medication. Methods Ninety-one cases of WT confirmed pathologically in the General Hospital of Armed Police Force from January 1 2006 to December 31 2016 were selected as subjects. They were divided into the localized non-metastatic group (73 cases) and pulmonary metastases alone group (18 cases) according to chest CT. The clinical data of patients in the two groups was reviewed while age, sex, primary tumor localization, initial symptoms, tumor volume, risk stratification, tumor stage and Ki-67 of these patients were analyzed. Results The percentage of children above 2 years old was 83.3% and 46.0%, respectively, in patients with PM and localized disease.The difference was statistically significant(P=0.005). During the first visit, the tumor volume of the patients in the lung metastatic group was larger than that of the non-pulmonary metastasis group, and the difference was statistically significant(P=0.017). There were significantly more cases of stage Ⅱ and stage Ⅲ (abdominal stage) disease among patients with PM than among patients without metastases (P=0.004). The occurrence of PM of nephroblastoma was not related to sex or the location of the tumor. The percentage of 2-year 0S was 36.1% among patients with PM alone compared with 86.0% among patients in the local stage. The difference was statistically significant (P=0.000 <0.01). Conclusions Patients with PM are generally significantly older and have larger tumor volumes upon diagnosis than those with localized diseases. There are far more stage Ⅱ and stage Ⅲ (abdominal stage)cases of disease among patients with PM than among patients without metastases. The total survival rate of patients with lung metastasis is lower than that of the non-lung metastasis group. Through the individualized comprehensive treatment, the chance and risks of WT can still be reduced to some extent, but OS is low. New treatment programs need to be studied to improve efficacy.

Key words： nephroblastoma pulmonary metastases clinical features relevant factor prognosis children

Received: 19 August 2017

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	Articles by authors
	GUAN Huihui
	LI Yanshan
	MIAO Lixia
	YUAN Hailian
	SUN Yanfeng
	WANG Jun
	ZHAO Yang
	LIU Qiuling

Cite this article:

GUAN Huihui,LI Yanshan,MIAO Lixia等. Clinical characteristics and related factors of pulmonary metastases in children with stage Ⅳ nephroblastoma[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(11): 1142-1146.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2017/V28/I11/1142

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