急性缺血性脑卒中早期神经功能恶化的影响因素

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Abstract Objective To investigate the effects of intravenous thrombolytic therapy and bridging therapy on early neurological deterioration(END) during acute ischemic stroke.Methods The clinical data on 112 patients with acute ischemic stroke who were treated with the intravenous thrombolytic therapy or the bridging therapy within the time window was retrospectively analyzed.These patients were subjected to three days of neurofunctional examinations after admission before they were divided into the END group and the non-END group according to the occurrence of END. The clinical data of the two groups was compared upon admission,including gender,age, hypertension,blood lipids,blood glucose and complications. Observation indexes (P<0.2) were entered into the binary Logistic regression analysis model to identify factors associated with END in case of acute inchemic stroke.Results Among the 112 cases of patients with acute ischemic cerebral infarction, there were 34 cases of END (30.4%).Indexes P<0.2 included gender,the interval between admission and treatment, pre- treatment neurologic function score(NIHSS),blood glucose, total cholesterol, complications with diabetes mellitus,and different therapies.The binary Logistic regression analysis suggested that according to the results of different treatments(OR=6.67,95%CI 1.24-34.93,P=0.025),lipid levels(total cholesterol,HDL and LDL)(OR=1.03,95%CI 1.01-1.06,P=0.034)diabetes control( a history of diabetes and fasting blood glucose levels)(OR=1.16,95%CI 1.03-1.31,P=0.017)were independent predictors of END.Conclusions Different treatments, blood glucose levels and blood lipid metabolic abnormalities in patients with acute ischemic cerebral infarction are factors related to END.

Key words： acute ischemic cerebral infarction intravenous thrombolytic therapy bridging therapy early neurological deterioration

Received: 21 April 2017

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	Articles by authors
	DONG Qiuyan
	FANG Lijuan
	SU Hui
	and BAI Zhihua

Cite this article:

DONG Qiuyan,FANG Lijuan,SU Hui等. Factors related to early neurological deterioration in acute ischemic stroke[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(1): 21-24.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I1/21

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