盐酸右美托咪定对老年髋部骨折患者术后谵妄的影响

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Abstract Objective To explore the effect of dexmetomidine on postoperative delirium in elderly patients with hip fracture.Methods One hundred and thirty-six postoperative patients with hip fracture and above 65 years old were randomly divided into 2 groups:dexmedetomidine group(n=69)and normal group (n=67).In dexmedetomidine group, the patients received dexmedetomidine by intravenous continuous infusion at 0.2 μg/(kg·h) within 20 minutes of their admission to the ICU.PCIA、VAS pain scores、 Ramsay sedation scores and the incidence of deliriumu were recorded at different time points after surgery.CAM-ICU was used to diagnose delirium.Results The total number of presses by PCIA, number of effective presses, drug consumption, SPO₂ and postoperative pain scores of these patients were not significantly different upon their admission to the ICU, 6 h and 12 h after surgery(P>0.05). Heart rate and MAP in the dexmedetomidine group were lower than in the normal group, but sedation scores were higher at the same time point and 6 h and 12 h after admission to the ICU. CRP was lower and hours of sleep were longer in the dexmedetomidine group than in the normal group. There were 7 cases of postoperative delirium (10.14%)in the dexmedetomidine group, but 20 cases (29.85%)in the normal group 12 hours after surgery. The difference between the two groups was statistically significant (P<0.05).Conclusions Continuous intravenous infusion of dexmetomidine can reduce the incidence of postoperative delirium in elder patients with hip fracture.

Key words： dexmedetomidine elderly patient analgesic and sedative postoperative delirium

Received: 20 June 2017

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	ZHENG Yanhui
	SHAO Lina

Cite this article:

ZHENG Yanhui,SHAO Lina. Influence of dexmedetomidine on postoperative delirium in elderly patients with hip fracture[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(3): 270-273.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I3/270

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