miRNAs对阿尔茨海默病诊断价值的Meta分析

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Abstract Objective To systematically review the diagnostic value of miRNAs for Alzheimer’s disease.Methods According to the inclusion and exclusion criteria, articles were selected from medical electronic databases, including Pubmed, Web of Science and CNKI. Meta-analysis was performed using Stata 13.0 software.Results A total of ten articles involving twenty studies were included. The Results of meta-analysis showed that the pooled Sen was 0.87[95%CI(0.79,0.91)],pooled Spe was 0.84[95%CI(0.79,0.91)],pooled PLR was 5.23[95%CI(3.04,9.24)],pooled NLR was 0.16[95%CI(0.10,0.26)],pooled DOR was 32.86[95%CI(13.73,78.59)],and the AUC of SROC was 0.92[95%CI(0.89,0.94)]. Conclusions Current evidence suggests that miRNAs may be a specific index to diagnose AD. But because of the limited quality and publication bias of the included studies, more high-quality studies are needed to verify the above conclusion.

Key words： Alzheimer’s disease miRNAs diagnosis meta-analysis

Received: 05 March 2019

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I7/584

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