FEV<sub>1</sub>/FVC对局限期小细胞肺癌预后的影响

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Abstract Objective To explore the effect of FEV1/FVC on the prognosis of limited stage small cell lung cancer.Methods The clinical data on 109 patients with small cell lung cancer treated at the First Affiliated Hospital of Xi’an Jiaotong University and our hospital between January 2012 and March 2015 was analyzed retrospectively. All the patients were treated with EP regimen chemotherapy and radiotherapy. Lung function was measured before treatment. The patients were divided into the experimental group (FEV₁/FVC<0.70) and control group (FEV₁/FVC<0.70). The correlations of FEV₁/FVC with clinical factors, survival time and the influencing factors were evaluated.Results FEV₁/FVC was closely related to patient mortality (P=0.008), local progression of small cell lung cancer (P=0.018) and distant metastasis (P=0.025). FEV₁ (%) was related to patient mortality. Univariate analysis showed that chemotherapy cycles, FEV₁% and FEV₁/FVC had significant effect on the overall survival of patients with limited stage small cell lung cancer (P<0.05). Multivariate analysis showed that FEV₁/FVC was an independent factor that influenced the overall survival of patients with limited stage small cell lung cancer. Age, chemotherapy cycle, FEV₁% and FEV₁/FVC had significant effect on progression-free survival of limited stage small cell lung cancer patients(P<0.05). Multivariate analysis showed that chemotherapy cycle and FEV₁/FVC were independent factors influencing the progression-free survival of patients with limited-stage small cell lung cancer (P<0.05). The total survival time of the experimental group (FEV₁/FVC<0.70) was significantly shortened, and the difference between the two groups was statistically significant (χ²=5.429, P<0.05).Conclusions FEV₁/FVC may be a good prognostic indicator for limited stage small cell lung cancer before treatment.

Key words： FEV₁/FVC small cell lung cancer

Received: 02 January 2019

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	Articles by authors
	XUE Song
	CHEN Yingxia
	QIN Shukui
	JIANG Zonghui
	DONG Xiangning

Cite this article:

XUE Song,CHEN Yingxia,QIN Shukui等. Effect of FEV₁/FVC on prognosis of limited stage small cell lung cancer[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(7): 607-610.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I7/607

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