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Effect of Compound Danshen Dropping Pills on retinas of patients with new type 2 diabetes mellitus |
SHI Baoquan1, MA Rongwei2, LIU Caixia3, WANG Pei4, LIU Tai5, SHEN Yong2, and WANG Rui6 |
1.Department of Pharmacy, 2. Internal One Departments, 3.Hospital Office, 4.Department of Health and Epidemiology, 5.Outpatient Department, 6.Second Department of Interral Medicine, Hebei Provincial Corps Hospital, Chinese People’s Armed Police Force, Shijiazhuang 050081, China |
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Abstract Objective To observe the effect of Compound Danshen Dropping Pills on retinopathy in newly diagnosed patients with type 2 diabetes mellitus.Methods Between January and August 2010, 72 outpatients and inpatients were selected, who received no diagnosis or treatment before being grouped. The follow-up lasted seven years.They were randomly divided into two groups: control group (34 cases) and observation group (38 cases). The control group received routine treatment of diabetes mellitus, while the observation group was treated with Compound Danshen Dropping Pills after six weeks of routine treatment.The changes of retinas during treatment were compared, and the relationships between fasting blood glucose, glycosylated hemoglobin, blood lipid and blood pressure were studied.Results (1) The change of TC in the two groups after treatment was statistically significant (P<0.05). LDL-C in the observation group was significantly different after treatment (P<0.05). After treatment, HDL-C of the two groups was significantly higher (P<0.05). In the control group increased slightly after 7 years of TG treatment, but decreased in the observation group after 5 and 7 years of TG treatment, and the difference between the two groups was statistically significant. However, there was no significant difference in FPG, HbA1c or blood pressure between the two groups before treatment and 7 years after treatment. (2) The incidence of DR in both groups increased gradually. After 7 years of treatment, the incidence in the observation group (9.6%) was lower than that in the control group (32.14%), so there was statistically significant difference between the two groups (P<0.05). 3) The incidence of DR in the control group after 7 years of treatment was significantly different from that in the control group after 5 years of treatment (P<0.05), but there was no statistically significant change in the observation group before and after treatment.Conclusions Compound Danshen Dropping Pills can delay the occurrence and development of DR.
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Received: 10 March 2019
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