来曲唑与他莫昔芬治疗特发性少精子症的疗效对比

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Abstract Objective To investigate the clinical effect of letrozole in the treatment of patients with idiopathic oligozoospermia.Methods A total of 150 patients with idiopathic oligozoospermia admitted to our hospital between April 2015 and January 2018 were divided into group A (n=50, letrozole tablets), group B (n=50, tamoxifen citrate) and group C (n=50, placebo) using random number table method. After 3 months of treatment, the sex hormone levels (E₂, T, FSH, LSH, PRL, T/E₂, INHB), general parameters of semen, testicular volume and BMI before and after treatment were compared.Results After treatment, the total effective rate of group A was significantly higher than that of group B and group C (96.0% vs 84.0% vs 28.0%, P<0.05). After treatment, the serum levels of FSH, LH, T, INH-B and T/E₂ ratios in group A were significantly higher than those in group B and group C, but the serum E₂ level was lower (P<0.05). After treatment, the sperm concentration, sperm count and normal sperm morphology in group A were significantly increased (P<0.05). The average effective sperm count increase in group A was significantly higher than that of group B and group C (P<0.05).Conclusions The use of letrozole in the treatment of idiopathic oligozoospermia can significantly improve the T and FSH levels, T/E₂ ratios as well as semen quality, which has a good clinical effect.

Key words： letrozole idiopathic oligozoospermia clinical efficacy sex hormone

Received: 17 June 2019

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	LI Xiaoxia
	DENG Xiaoling
	WANG Shuhong
	LI Xing

Cite this article:

LI Xiaoxia,DENG Xiaoling,WANG Shuhong等. Clinical efficacy of letrozole and tamoxifen in the treatment of patients with idiopathic oligozoospermia[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(9): 780-783.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I9/780

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