|
|
|
|
|
Received: 10 February 2019
|
|
|
|
|
|
| [1] |
郭力生.防原医学[M].北京:原子能出版社,2006:64-65.
|
| [2] |
朱丽娜,武文辉,廖玮浩,等. 放射性肠炎的发病机制及其治疗进展[J]. 临床医学研究与实践, 2018,3(7):196-198.
|
| [3] |
陈 晓,王箫剑,周 平.放射性胃、十二指肠黏膜屏障损伤的发生机制[J].临床与病理杂志, 2015,35(12):2191-2194.
|
| [4] |
Tan Y, Guan Y, Sun Y, et al. Correlation of intestinal mucosal healing and tight junction protein expression in ulcerative colitis patients[J]. Am. J. Med. Sci, 2019, 357(3): 195-204.
|
| [5] |
Runkle E A, Mu D. Tight junction proteins: from barrier to tumorigenesis[J]. Cancer Lett, 2013, 337(1): 41-48.
|
| [6] |
翟双双.肠道黏膜屏障机能及其调控研究进展[J].现代畜牧兽医,2014(7):54-58.
|
| [7] |
Mantis N J, Forbes S J. Secretory IgA: arresting microbial pathogens at epithelial borders[J]. Immunol Invest, 2010, 39(45): 383-406.
|
| [8] |
Boullier S, Tanguy M, Kadaoui K A, et al.Secretory IgA-mediated neutralization of shigella flexneri prevents intestinal tissue destructionby down-regulating inflammatory circuits[J]. J lmmunol, 2009, 183(9): 5879-5885.
|
| [9] |
Shim S, Jang H S, Myung H W, et al. Rebamipide ameliorates radiation-induced intestinal injury in a mouse model[J]. Toxicol Appl Pharmacol, 2017,8(15): 329.
|
| [10] |
Mishra K N, Moftah B A, Alsbeih G A. Appraisal of mechanisms of radioprotection and therapeutic approaches of radiation countermeasures.[J]. Biomed Pharmacother, 2018, 106: 610-617.
|
| [11] |
Farhood B,Goradel N H. Intercellular communications-redox interactions in radiation toxicity; potential targets for radiation mitigation[J].J Cell Commun Signal, 2019, 13(1): 3-16.
|
| [12] |
Morini J, Babini G, Barbieri S, et al. The Interplay between radioresistant caco-2 cells and the immune system increases epithelial layer permeability and alters signaling protein spectrum[J]. Front Immunol, 2017, 8: 223.
|
| [13] |
Khan N,Pantakani D V,Binder L, et al. Immunosuppressant MPA modulates tight junction through epigenetic activation of MLCK/MLC-2 pathway via p38MAPK[J]. Front Physiol, 2015, 6: 381.
|
| [14] |
Sadi R, Guo S, Ye D, et al. TNF-α Modulation of intestinal tight junction permeability is mediated by NIK /IKK-α axis activation of the canonical NF-κB pathway[J]. Am J Pathol, 2016, 186 (5) : 1151-1165.
|
| [15] |
Jo H, Hwang D, Kim J K, et al. Oxyresveratrol improves tight junction integrity through the PKC and MAPK signaling pathways in Caco-2 cells[J]. Food Chem Toxicol, 2017, 108 ( Pt A) : 203-213.
|
| [16] |
Le Dréan G, Haure M V, Ferrier L, et al. Visceral adipose tissue and leptin increase colonic epithelial tight junction permeability via a RhoA-ROCK-dependent pathway[J]. FASEB J, 2014, 28 (3) : 1059-1070.
|
| [17] |
Sha H X, Gu Y, Shen W X, et al. Rheinic acid ameliorates radiation-induced acute enteritis in rats through PPAR-γ/NF-κB[J]. Genes Genomics, 2019,12(3):1450.
|
| [18] |
张希梅,王佩国,袁智勇,等.对放射性肠炎的认识及其可能的机制探讨[J].中华放射肿瘤学杂志,2017, 26(9): 1099-1102.
|
| [19] |
王中秋,王清鑫,袁智勇.放射性肠炎肠黏膜屏障损伤及其相关机制的研究进展[J].胃肠病学, 2018, 23(7):62-65.
|
| [20] |
Ong Z Y, Gibson R J, Bowen J M, et al. Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis[J]. Radiat Oncol, 2010, 5(1):22.
|
| [21] |
Linard C, Ropenga A, Vozenin M C, et al. Abdominal irradiation increases inflammatory cytokine expression and activates NF-kappaB in rat ileal muscularis layer[J]. Am J Physiol Gastrointest Liver Physiol, 2003, 285 (3): 556-565.
|
| [22] |
Chipuk J E, Green D R. Dissecting p5-dependent apotosis[J]. Cell Death Differ, 2006, 13(6): 994-1002.
|
| [23] |
Bing S J, Kim M J, Ahn G, et al. Acidic polysaccharide of panax ginseng regulates the mitochondria /caspase-dependent apoptotic pathway in radiation-induced damage to the jejunum in mice[J]. Acta Histochem, 2014, 116(3): 514-521.
|
| [24] |
Tan C, Liu L, Liu X, et al. Activation of PTGS2/NF-κB signaling pathway enhances radiation resistance of glioma.[J]. Cancer Med, 2019, 8(3): 1-11.
|
| [25] |
王 静,章越凡,李铁军.辐射防护相关信号通路研究现状[J].药学实践杂志,2017,35(1):8-11.
|
| [26] |
Ikeda A, Sun X, Li Y, et al. p300/CBP-dependent and-independent transcriptional interference between NF-kappaB RelA and p53[J]. Biochem Biophys Res Commun, 2000, 272(2): 375-379.
|
| [27] |
王兴鹏.肠道屏障功能障碍[M].上海:第二军医大学出版社,2006: 351-356.
|
| [28] |
Aparicio D P, Romera H M, Karrich J J, et al. Type3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage [J] . J Exp Med, 2015, 212: 1783-1791.
|
| [29] |
方健松.自噬介导肠黏膜屏障维持肠道稳态在炎症性肠病中的作用[C].中华中医药学会脾胃病分会第二十八届全国脾胃病学术交流会论文集.2016:461.
|
| [30] |
方健松,马媛萍,刘 畅,等.自噬介导肠黏膜屏障维持肠道稳态在炎症性肠病中的作用[J]. 实用医学杂志, 2016, 32(8):1367-1369.
|
| [31] |
Chen Q, Xia X, Wu S, et al. Apoptosis, necrosis, and autophagy in mouse intestinal damage after 15-Gy whole body irradiation[J]. Cell Biochem Funct, 2015, 32(8): 647-656.
|
| [32] |
Touchefeu Y, Montassier E, Nieman K, et al. Systematic review: the role of the gut microbiota in chemotherapy or radiation-induced gastrointestinal mucositis - current evidence and potential clinical applications[J]. Aliment Pharmacol Ther, 2014, 40(5): 409-421.
|
| [33] |
Kanarek N, Grivennikov S I, Leshets M, et al. Critical role for IL-1β in DNA damage-induced mucositis[J]. Proc Natl Acad Sci USA, 2014, 111(6): 702-711.
|
| [34] |
Kuiken N S, Rings E H, Tissing W J. Risk analysis, diagnosis and management of gastrointestinal mucositis in pediatric cancer patients[J]. Crit Rev Oncol Hematol, 2015, 94(1): 87-97.
|
| [35] |
Zou F, Mao R, Yang L, et al.Targeted deletion of miR-139-5p activates MAPK, NF-κB and STAT3 signaling and promotes intestinal inflammation and colorectal cancer[J]. FEBS J, 2016, 283(8): 1438-1452.
|
| [36] |
Beck P L,Wong J F,Li Y, et al. Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor[J]. Gastroenterology, 2004, 126(3): 796-808.
|
| [37] |
Chairatana P, Nolan E M. Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut[J]. Crit Rev Biochem Mol Biol, 2017, 52(1): 45-56.
|
| [38] |
赵致维,崔 宇,王丽梅,等. 氨磷汀对小鼠肠型急性放射病的防护作用及其机制[J]. 武警医学, 2015, 26(8):797-800.
|
| [39] |
Demers M, Dagnault A, Desjardins.A randomized double-blind controlled trial:impact of probioticson diarrhea in patients treated with pelvic radiation[J]. Clin Nutr, 2014, 33(5): 761-767.
|
| [40] |
Hu C, Song J, You Z, et al. Zinc oxide-montmorilionite hybrid influences diarrhea, intestinal mucosal integrity, and digestive enzyme activity in weaned pigs[J]. Biol Trace Elem Res, 2012, 149(2):190-196.
|
| [41] |
关丽愉.美沙拉嗪栓剂治疗10例慢性难治性放射性直肠炎的疗效观察[D].南宁:广西医科大学, 2015.
|
| [42] |
陆清昀.中药口服加灌肠治疗放射性肠炎43例疗效观察[J].四川中医, 2017,12(1):71-73.
|
| [43] |
朱丽娜,武文辉,廖玮浩,等.放射性肠炎的发病机制及其治疗进展[J].临床医学研究与实践,2018, 3(7):196-198.
|
| [44] |
刘 亭,杨彬珧,雷 超,等.亲属供体粪菌移植缓解放射性肠炎病案报告[J].中医药临床杂志,2018, 30(3):445-447.
|
|
|
2019, Vol. 30 
