前列地尔对早期2型糖尿病合并高血压患者血管内皮功能及氧化物质的影响

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (842 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the protective effect of valsartan combined with alprostadil on the function of vascular endothelium and the effect on the concentration of oxidants in patients with early type 2 diabetes mellitus (T2DM) complicated with hypertension.Methods Between May 2017 and September 2018, 100 patients with early type 2 diabetes mellitus (T2DM) complicated with hypertension but without microangiopathy were selected and randomly divided into the control group (n=50) and observation group (n=50). Both groups were treated with hypotensive drugs (valsartan), hypoglycemic drugs (metformin+acarbose tablets) and improved circulation (ginkgo biloba extract), but the observation group was additionally given alprostadil. After 60 days of continuous treatment, the levels of fasting blood glucose (FBG) and postprandial 2-hour blood glucose (2 h PBG), body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), the concentration of vasodilators [nitric oxide (NO), endothelin-1 (ET-1), vascular endothelial growth factor (VEGF)] and its flow-mediated endothelium-dependent vasodilation of the brachial artery (FMD), nitroglycerin mediated endothelium-independent vasodilation (NMD), oxidation-related substances (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), reactive oxygen species (ROS) activity, and the concentration of malondialdehyde (MDA) were observed. The clinical efficacy was evaluated and the adverse reactions during the treatment were recorded.Results After treatment, FBG and PBG in the two groups were significantly lower (P＜0.05), but there was no significant difference in BMI between the two groups (P＞0.05).There was no significant difference in FBG, PBG or BMI between the two groups after treatment (P＞0.05). After treatment, SBP, DBP, ET-1, VEGF, ROS and MDA in the two groups were lower, and the difference was statistically significant (P＜0.05). After treatment, SBP, DBP, ET-1, VEGF, ROS and MDA in the observation group were significantly lower than those in the control group (P＜0.05). After treatment, NO, FMD, NMD, SOD and GSH-Px in the two groups were higher. The difference was statistically significant (P＜0.05). After treatment, NO, FMD, NMD, SOD and GSH-Px in the observation group were significantly higher than in the control group (P＜0.05). There was no serious adverse reaction (AEs) in either group, but such mild gastrointestinal reaction as rash and dry cough occurred in both groups, and there was no significant difference in the incidence between the two groups.Conclusions On the basis of hypoglycemic and hypotensive treatment, alprostadil can improve vascular endothelial function, improve the imbalance between oxidation and antioxidation, and improve the clinical effect in patients with T2DM complicated with hypertension without microangiopathy in the early stage.

Key words： type 2 diabetes mellitus hypertension mental nursing vascular endothelium valsartan alprostadil oxidation related substances

Received: 10 February 2019

ZTFLH:	R544.11
	R587.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHAO Yueping
	SUN Zhe
	LIU Jing
	YUAN Feiyang
	SUN Mengmeng
	SU Hong
	and SONG Tao

Cite this article:

ZHAO Yueping,SUN Zhe,LIU Jing等. Protective effect of valsartan combined with alprostadil in the vascular endothelium of patients with T2DM and hypertension and the effect on oxidation substances[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(10): 829-833.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I10/829

[1]	胡静涛. 通心络胶囊对高血压伴2型糖尿病患者血管内皮功能和氧化应激的影响 [J]. 河南中医, 2017, 37 (5): 805-807.
[2]	储苏平, 傅琼. 厄贝沙坦与厄贝沙坦氢氯噻嗪治疗糖尿病合并高血压的疗效比较 [J]. 中国糖尿病杂志, 2013, 21 (7): 622-624.
[3]	董时广, 苏桦, 欧阳乐宣, 等. 缬沙坦联合氨氯地平治疗社区高血压合并糖尿病患者疗效观察 [J]. 海南医学, 2015, 26 (3): 345-347.
[4]	Ehlinger M, Scheibling B, Rahme M, et al. Minimally invasive surgery with locking plate for periprosthetic femoral fractures: technical note[J]. Int Orthop, 2015, 39 (10): 1921-1926.
[5]	American Diabetes Association. Standards of medical care in diabetes 2007 [J]. Diabetes Care, 2011, 34 (Suppl. 1): S11-S61.
[6]	李为民. 心血管疾病诊断治疗指南 [J]. 中国实用内科杂志, 2007, 27 (12): 899-902.
[7]	康国强, 陈树强, 程祖建, 等. 高血压患者血管内皮功能和血清脂肪细胞因子的变化及氯沙坦干预的作用 [J]. 临床心血管病杂志, 2012, 28 (10): 774-777.
[8]	郑峰, 姜燕, 江蕾, 等. 血管舒张功能评价长期血液灌流串联血液透析对患者血管内皮功能的价值 [J]. 安徽医学, 2017, 38 (4): 411-414.
[9]	刘国仗, 胡大一, 陶萍, 等. 心血管药物临床试验评价方法的建议[J]. 中华心血管病杂志, 1998, 26 (4): 7-8.
[10]	边涛, 李云, 杨鹏. 2型糖尿病合并高血压患者高敏C反应蛋白与肱踝脉搏波速度的变化及其临床意义[J]. 中国糖尿病杂志, 2013, 21 (5): 419-421.
[11]	Guan Q, Liu W, Liu Y, et al. High glucose induces the release of endothelin-1 through the inhibition of hydrogen sulfide production in HUVECs [J]. Int J Mol Med, 2015, 35 (3): 810-814.
[12]	Lundberg J O, Gladwin W T, Weitzberg E. Strategies to increase nitric oxide signalling in cardiovascular disease [J]. Nat Rev Drug Discov, 2015, 14 (9): 623-641.
[13]	鞠文浩, 刘金波, 赵红薇, 等. 高盐饮食对健康人和高血压患者血浆血管内皮生长因子C水平的影响及其与血压的相关性研究 [J]. 中国循环杂志, 2018, 33 (4): 346-350.
[14]	蒲艳, 邹庆伟, 蒲敏. 缬沙坦分散片与雷公藤多甙在治疗78例糖尿病肾病蛋白尿中的效果分析 [J]. 吉林医学, 2013, 34(28): 6789-6791.