VEGF/PTEN及下游信号通路在侵袭性垂体瘤中的表达及其临床意义

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Abstract Objective To analyze the expressions of vascular endothelial growth factor (VEGF), gene of phosphate and tension homology deleted on chromosome ten (PTEN), and downstream signaling pathways in invasive pituitary adenomas.Methods Sixty-two cases of pituitary adenomas (32 invasive and 30 non-invasive tumors) and 60 cases of normal pituitary glands were selected. The expressions of PTEN/VEGF, their downstream phosphate-serine/threonine kinase (p-Akt) and phosphate-mitogen-activated protein kinase (p-MAPK) signaling pathways in all the pituitary adenomas and normal pituitary glands were detected by quantitative polymerase chain reaction and Western blot.Results (1)There was a significant decrease of PTEN and notable increase of VEGF in patients with pituitary adenomas compared to the normal controls(P<0.05). Meanwhile, the expression levels of PTEN (0.42±0.10)and VEGF(3.61±0.16) in the invasive pituitary adenomas were significantly different from those in the non- invasive pituitary adenomas (PTEN 0.86±0.11, VEGF 2.06±0.13) (PTEN t=6.31,P<0.05; VEGF t=10.60, P<0.05).(2) Levels of p-Akt and p-MAPK in the pituitary adenoma group were notably increased compared with the control group(P<0.05), whereas the invasive pituitary adenomas(p-Akt 3.90±0.14; p-MAPK 2.52±0.11) showed a statistically significant increase compared with the non- invasive pituitary adenomas(p-Akt 2.27±0.11; p-MAPK 1.89±0.05)(p-Akt, t=12.95, P<0.05; p-MAPK t=7.29, P<0.05).Conclusions Our study has offered evidence that there is a significant decrease of PTEN and notable increase of VEGF, p-Akt and p-MAPK in invasive pituitary adenomas, suggesting that these changes may be related to the invasiveness of pituitary adenomas. These findings can facilitate the diagnosis and treatment of invasive pituitary adenomas.

Key words： pituitary adenomas invasive pituitary adenomas gene of phosphate and tension homology deleted on chromosome ten vascular endothelial growth factor phosphate serine/threonine kinase phosphate mitogen activated protein kinase

Received: 01 May 2019

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	Articles by authors
	MAO Jianhui
	SUN Zhaosheng
	GUO Hong
	WEI Jianhui
	SI Na
	QIU Lei
	GUO Lianfeng
	and ZHENG Lei

Cite this article:

MAO Jianhui,SUN Zhaosheng,GUO Hong等. Expressions of VEGF, PTEN, and downstream signaling pathways in invasive pituitary adenomas[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(10): 866-869.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I10/866

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