斑蝥酸钠维生素B<sub>6</sub>注射液对乳腺癌辅助化疗患者血清IL-6、IL-17、TNF-α及MIF表达水平的影响

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Abstract Objective To investigate the effects of sodium cantharidate and vitamin B₆ injection on levels of serum interleukin (IL)-6, IL-17, tumor necrosis factor (TNF)-α and Macrophage migration inhibitory factor (MIF) in patients with breast cancer under adjuvant chemotherapy.Methods One hundred and twenty-two patients with advanced breast cancer who were treated between May 2014 and June 2018 were selected as subjects and divided into the study group(n=62) and the control group (n=60) according to treatment methods. The control group received conventional chemotherapy, while the study group was additionally given sodium cantharidate and vitamin B₆ injection. The two groups were treated with chemotherapy for four cycles, and the expression levels of IL-6, IL-17, TNF-α and MIF were recorded.Results The total effective rate of the study group after chemotherapy was 67.7%, which was significantly higher than that of the control group (33.3%) (P<0.05). There was no significant difference in the incidence of such toxic side effects as myelosuppression, digestive tract reaction, alopecia or thrombocytopenia between the two groups. The levels of serum IL-6, IL-17, TNF-α and MIF in the two groups were significantly lower after chemotherapy (P<0.05), especially in the study group (P<0.05). The levels of CD3⁺ and CD4⁺ in the study group were significantly higher after chemotherapy (P<0.05), especially in the study group (P<0.05), but there was no significant change in the control group after chemotherapy. KM analysis showed that the overall survival and progression-free survival of the study group were significantly longer than those of the control group (P<0.05).Conclusions The application of sodium cantharidate and vitamin B₆ injection in breast cancer adjuvant chemotherapy can inhibit the expressions of serum IL-6, IL-17, TNF-α and MIF, improve the immune function of patients and enhance the effect of chemotherapy The occurrence of toxic and side effects will not increase, thereby prolonging the survival of patients.

Key words： sodium cantharidate vitamin B₆ injection breast cancer chemotherapy interleukin-6 macrophage migration inhibitory factor

Received: 13 March 2019

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	Articles by authors
	GUO Xiaoying
	SHEN Guohong
	and ZHAO Bin

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GUO Xiaoying,SHEN Guohong,and ZHAO Bin. Effects of sodium cantharidate and vitamin B₆ injection on serum IL-6, IL-17, TNF-α and MIF expressions in patients with breast cancer under adjuvant chemotherapy[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(10): 885-889.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I10/885

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