嗜酸性粒细胞高低对慢性阻塞性肺疾病急性加重期是否应用激素的指导价值

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Abstract Objective To explore the role of peripheral blood eosinophils in the hormone therapy for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 224 patients with acute exacerbation of chronic obstructive pulmonary disease admitted to our hospital between January 2016 and October 2017 were divided into four groups according to the levels of peripheral blood eosinophils and the selection of hormone therapy:the hormone treatment group (group A) with elevated blood EOS, hormone treatment group with normal blood EOS (group B), non-hormone treatment group with elevated blood EOS (group C), and non-hormone treatment group with normal blood EOS (group D). Information about the gender, age, comorbidities, CAT scores, blood analysis, blood gas analysis, lung function, and nitric oxide breath test of these patients was collected. All the four groups were given oxygen, anti-inflammatory and antiasthmatic treatment,phlegm reduction and other general treatments, but Group A and group B additionally received hormone therapy. After one week, the results of blood analysis, FENO and CAT score of all these were reviewed. The length of hospital stay and rehospitalization rate of the four groups 3 months after discharge were recorded. Statistical analysis was conducted. Results There was no statistically significant difference in the general data, blood gas analysis, hemoglobin or lung function between the four groups. The average length of hospital stay was the shortest in group A and the rate of re-hospitalization 3 months after discharge was also the lowest, with statistically significant differences (P<0.05). Conclusions Peripheral blood eosinophils are of great importance in the hormone therapy for acute exacerbation of chronic obstructive pulmonary disease.

Key words： acute exacerbation of chronic obstructive pulmonary disease eosinophils hormone therapy rehospitalization rate

Received: 20 February 2019

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	DONG Shaochen
	YU Hongmin
	ZHAO Dongmei
	QIAO Hua

Cite this article:

DONG Shaochen,YU Hongmin,ZHAO Dongmei等. Role of eosinophils in hormone therapy for acute exacerbation of COPD[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(2): 114-117.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2020/V31/I2/114

[1]	中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013 年修订版)[J].中华结核和呼吸杂志,2013,36(4):245-246.
[2]	Saha S, Brightling C E. Eosinophilic airway inflammation in COPD[J]. Int J Chron Obstruct Pulmon,2006,1(1):39-47.
[3]	胡红,韩国敬. 哮喘-慢阻肺重叠综合征的诊治进展[J]. 武警医学,2016,27(9):865-870.
[4]	Kohei H, Carlos A,Camargo J. Prevalence of blood eosinophilia in hospitalized patients with acute exacerbation of COPD[J]. Respirology,2016, 21:761-764.
[5]	Pascoe S, Locantore N, Dransfield M T, et al. Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials[J]. Lancet Respir Med,2015,3(6):435-442.
[6]	中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013 年修订版)[J].中华结核和呼吸杂志,2013,36(4):255-264.
[7]	Hasegawa K,Camargo, J R. Prevalence of blood eosinophilia in hospitalized patients with acute exacerbation of COPD [J]. Respirology, 2016. 21(4):761 - 764.
[8]	Panzner P, Lafitte J, Tsicopoulos A, et al. Marked upregulation of T lymphocytes and expression of interleukin-9 in bronchial biopsies from patients With chronic bronchitis with obstruction[J]. Chest,2003,124(5):1909-1915.
[9]	Riise G C, Ahlstedt S, Larsson S, et al. Bronchial inflammation in chronic bronchitis assessed by measurement of cell products in bronchial lavage fluid[J]. Thorax,1995,50(4):360-365.
[10]	郑春明,李论,黄克武.外周血嗜酸性粒细胞与慢性阻塞性肺疾病急性加重期住院患者临床转归的相关性分析[J]。中国临床医生杂志.2016, 44(10):42-44.
[11]	Bafadhel M, Greening N G, Harvey T C, et al. Blood eosinophils and outcomes in severe hospitalized exacerbations of COPD[J]. Chest,2016,150(2) :320-328.
[12]	Cheng S L, Lin C H. Effectiveness using higher inhaled corticosteroid dosage in patients with COPD by different blood eosinophilic counts[J]. Int J Chron Obstruct Pulmon Dis,2016, 21(11):2341-2348.