局部晚期乳腺癌新辅助化疗十年疗效评价与影响因素分析

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Abstract Objective To explore the influencing factors of the curative effect and prognosis of patients with breast cancer who have undergone neoadjuvant chemotherapy.Methods The clinicopathologic data on 190 locally advanced breast cancer patients receiving neoadjuvant chemotherapy was retrospectively collected and the factors that influenced pathologic complete response and prognosis of patients after neoadjuvant chemotherapy were analyzed.Results Among the 190 patients, 22 cases (11.58%) had pathological complete response after neoadjuvant chemotherapy. Univariate analysis showed that the expression level of ki-67, chemotherapy regimen and Luminal typing were correlated with PCR (P<0.05). Multivariate analysis showed that the expression level of ki-67 was an independent factor influencing the pathological complete response after neoadjuvant chemotherapy (P<0.05). The overall 10-year survival rate was 56.3%. Multivariate analysis showed that PCR was an independent factor affecting the survival rate of breast cancer patients after neoadjuvant chemotherapy (P<0.05).Conclusions Ki-67 is an independent factor that affects pathological complete response after neoadjuvant chemotherapy for breast cancer while PCR is an independent factor influencing the prognosis of breast cancer patients after neoadjuvant chemotherapy.

Key words： breast cancer neoadjuvant chemotherapy prognosis Ki-67 pCR

Received: 03 January 2020

ZTFLH:	R284.1
	R917.101

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	Articles by authors
	HU Chen
	JIA Zhilong
	WEI Xiaochen
	ZHU Liqin

Cite this article:

HU Chen,JIA Zhilong,WEI Xiaochen等. Long-term evaluation of neoadjuvant chemotherapy for breast cancer and influencing factors[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(3): 224-228.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2020/V31/I3/224

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