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| Effect of non-invasive mechanical ventilation on levels of α-HBDH, β-EP, MMP-9 and TIMP-1 in elderly patients with COPD and respiratory failure |
| WANG Na1, LI Qiang2, XU Wen3, ZHANG Lin1, GONG Baiqi1, YUN Wenke4 |
1.The Third Department of Internal Medicine,2.Department of Critical Care Medicine,3.Department of Specific Care, Beijing Municipal Corps Hospital, Chinese People’s Armed Police Force, Beijing 100027, China;
4.Inner Mongolia Corps Hospital,Chinese People's Armed Police Force,Hohhot 010010,China |
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Abstract Objective To explore the effect of non-invasive mechanical ventilation therapy on levels of α-hydroxybutyrate dehydrogenase (αHBDH), β-endorphin (β-EP), metalloproteinase-9 (MMP-9) and tissue inhibitory factor-1 (TIMP-1) in elderly patients with chronic obstructive pulmonary disease (COPD) complicated with respiratory failure.Methods Seventy-six cases of elderly patients with COPD and respiratory failure were selected as the subjects, who were randomly and equally divided into two groups. The control group was treated with tiotropium bromide, while the experimental group was additionally treated with non-invasive mechanical ventilation. The levels ofα-HBD, β-EP, MMP-9 and TIMP-1 were compared between two groups.Results After treatment, levels ofα-HBDH and β-EP were lower in the experimental group than in the control group, respectively, so were the levels of MMP-9 and TIMP-1, with statistically significant significance(P<0.05). After treatment, the walking distance of the experimental group was longer than that of the control group, and the St. George’s breathing questionnaire score was lower than that of the control group, with statistically significant difference(P<0.05).Conclusions Non-invasive mechanical ventilation used for elderly patients with COPD and respiratory failure can effectively reduce the levels of αHBDH, β-EP, MMP-9 and TIMP-1, thereby promoting the relief of patients’ conditions.
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Received: 10 February 2020
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| [1] |
王 聪.不同通气法对COPD合并呼吸衰竭患者的疗效及预后研究[J].陕西医学杂志,2017,46(8):1048-1050.
|
| [2] |
Ozsancak Ugurlu A, Habesoglu M A. Epidemiology of NIV for acute respiratory failure in COPD Patients: results from the international surveys vs. the “Real World”[J] COPD, 2017,14(4):1-10.
|
| [3] |
王建华,胡贵芳,蒋世碧,等.无创机械通气对慢性阻塞性肺疾病合并呼吸衰竭患者睡眠、认知功能的影响[J].国际呼吸杂志,2018,38(19):1465-1469.
|
| [4] |
中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013年修订版)(一)[J].中华结核和呼吸杂志,2013,36(4):255-264
|
| [5] |
梁立媛,王红阳.规律联合吸入长效支气管扩张剂对重度、极重度COPD稳定期患者的临床价值[J].中国临床研究,2017,30(1):81-83.
|
| [6] |
Furukawa T , Taniguchi H , Ando M ,et al. The St. George’s Respiratory Questionnaire as a prognostic factor in IPF[J].Respir Res,2017,18(1):18-18.
|
| [7] |
唐国清.无创通气联合支气管镜治疗COPD合并呼吸衰竭的效果观察[J].现代中西医结合杂志,2017,26(29):77-80.
|
| [8] |
康剑云,曹保森,张学林,等.噻托溴铵联合沙美特罗替卡松治疗老年重度COPD的临床观察[J].中国药房,2017,28(20):2830-2833.
|
| [9] |
李艳霞,刘 卓,尹 燕,等.无创机械通气治疗对慢性阻塞性肺疾病急性加重期患者血浆脑钠肽表达的影响[J].四川医学,2017,38(10):37-40.
|
| [10] |
邓小军,杨丽萍.纤维支气管镜下氨溴索肺泡灌洗对重症肺炎合并呼吸衰竭患者SIRS及靶器官功能损伤的影响[J].海南医学院学报,2017,23(14):1889-1891.
|
| [11] |
王凌志,柴纪严,刘旭东,等.β-内啡肽过度释放参与脾气虚纳少和腹胀的形成[J].中国中医基础医学杂志,2017,13(2):42-44.
|
| [12] |
李小龙,王荣丽.二甲双胍灌胃对支气管哮喘小鼠气道重塑的影响及机制探讨[J].山东医药,2017,57(47):38-41.
|
| [13] |
Zhou X M, Hou G,Gu D X,et al. Peroxisome proliferator-activated receptor-γ in induced sputum is correlated with MMP-9/TIMP-1 imbalance and formation of emphysema in COPD patients[J].J Thorac Dis,2017,9(10):3703-3710.
|
| [14] |
苏海兵,李杰.噻托溴铵辅助治疗对COPD合并Ⅱ型呼吸衰竭患者氧合功能及炎症反应的影响[J].海南医学院学报,2017,23(4):40-43.
|
| [15] |
赵 飞,刘志光,张卫东.家庭无创机械通气治疗稳定期重度慢性阻塞性肺疾病的疗效观察[J].医学临床研究,2018,35(2):260-262.
|
| [1] |
. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(5): 441-445. |
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2020, Vol. 31 
