补肾活血法辅助奥沙利铂治疗消化道肿瘤的效果

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Abstract Objective To evaluate the clinical efficacy of Bushen Huoxue therapy against peripheral neurotoxicity induced by oxaliplatin.Methods A retrospective clinical case series of 48 patients with gastric cancer and colorectal cancer were included and reviewed in the study. These patients were divided into a TCM treatment group and a Western medicine control group, with 24 cases in each. The control group was treated with oxaliplatin plus capecitabine chemotherapy, and vitamin B6 was administered orally while the treatment group was supplemented with kidney-replenishing and blood-promoting Chinese medicine orally. The changes in peripheral neurotoxicity grades and KPS scores of the two groups were recorded and analyzed during four cycles of chemotherapy.Results Because of the low incidence of peripheral neurotoxicity in the first and second chemotherapy cycles, the difference in grades of peripheral neurotoxicity was not significant between the two groups. In the third cycle of chemotherapy, peripheral neurotoxicity was not detected in 9 cases, but 10 cases were found with Grade 1, and 5 cases with Grade 2 in the treatment group, compared to 4 cases, 9 cases and 11 cases respectively in the control group. The grade of peripheral neurotoxicity in the treatment group was lower than that in the control group, and the difference was statistically significant (P<0.05). In the fourth cycle of chemotherapy, 5 cases didn’t suffer from peripheral neurotoxicity, but 11 cases were found with Grade 1, 7 cases with Grade 2 , and 1 case with Grade 3 in the treatment group, compared to 3 cases, 6 cases, 9 cases and 6 cases in the control group. After four cycles of chemotherapy, the KPS score of the treatment group was significantly improved to 77.5(70.0,87.5), compared to 70(70.0,87.5)in the control group, and the difference was statistically significant.Conclusions The Chinese herbs for tonifying the kidney and promoting blood circulation can reduce peripheral neurotoxicity more effectively than Western medicine alone

Key words： Bushen Huoxue gastrointestinal tumor oxaliplatin peripheral neurotoxicity

Received: 03 April 2020

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	GUO Yunxia
	MENG Shuai
	LI Yiming
	WANG Ruojin
	LI Shaodan

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GUO Yunxia,MENG Shuai,LI Yiming等. Clinical efficacy of Bushen Huoxue therapy against peripheral neurotoxicity induced by oxaliplatin[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(8): 707-710.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2020/V31/I8/707

[1]	郑荣寿,孙可欣,张思维,等.2015年中国恶性肿瘤流行情况分析[J].中华肿瘤杂志,2019,41(1):19-28.
[2]	Cassidy J, Misset J L. OxaIiplatin-related side effects: characteristics and management [J].Semin Oncol, 2002, 29(5):11-20.
[3]	Cats A. New developments in systemic chemotherapy in advanced colorectal cancer [J].Stand J Gastroenterol Supp1,2003,38(239):78-86.
[4]	Jaggi A S, Singh N. Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy[J]. Toxicology, 2012, 291:1-9.
[5]	Wilson R H, Lehky T, Thomas R R, et al. Acute oxaliplatin-induced peripheral nerve hyperexcitability [J]. J Clin Oncol, 2002, 20(7):1767.
[6]	王媛媛,邓博,段锦龙,等.温经通络散外用对奥沙利铂周围神经毒性大鼠神经保护作用的研究[J].中华中医药杂志,2015,30(8):2917-2920.
[7]	黄攀,潘迎英,刘莲芳.中药足浴防治奥沙利铂神经毒性的临床观察[J].山东中医杂志,2016, 35(20):136-137.
[8]	陈荣生,陈其然.通脉活血汤防治奥沙利铂周围神经毒性的效果观察[J].河北中医,2017,39(4):543-546.
[9]	黄海福,苏碧莹.黄芪桂枝五物汤联合温针治疗奥沙利铂周围神经毒性的理论探讨[J].中国民族民间医药,2018,27(16): 7-9.
[10]	何凤生,薛启莫.神经病学[M].北京:人民军医出版社, 2002:174.
[11]	Levi F, Misset J L, Brienza S, et al. A chronophamacologic phase II clinical trial with 5-fluorouracial,folinc acid, and oxaliplatin using an ambulatory multichannel programmable pump. High antitumor effectiveness against metastatic colorectal cancer[J]. Cancer, 1992, 69(4):893-900.
[12]	孙燕,石远凯.临床肿瘤内科手册[M].北京:人民卫生出版社,2007: 258-259.
[13]	马飞,袁芃,徐泉,等.奥沙利铂所致急性神经毒性的临床分析及其治疗(附1例报告)[J].临床肿瘤学杂志,2005,10(5):533-535.
[14]	Schemelz R, Lersch C.Acute oxaliplatin-induced periph-eral-nerve hyperexcitability [J].J Clin Oncol, 2002, 20(16):3561-3562
[15]	王宗伟,黄兆胜.植物鞣质的药理作用及结构特征[J].国外医药中医中药分册,1997,19(2):2223.
[16]	臧莲碧,郑怡健.山茱萸对小鼠抗氧化酶活力的影响[J].中国中医药科技,1994,1(6):35.
[17]	马慧,尹若熙,郭敏,等.肉苁蓉多糖对D-半乳糖致衰老模型小鼠CREB表达的影响[J].中国实验方剂学杂志,2014,20(20):137-141.
[18]	由淑萍,赵军,马龙,等.肉苁蓉乙醇提取物抗大鼠免疫性肝纤维化的作用及其机制[J].中国药理学与毒理学杂志,2016,30(5):504-510.
[19]	许政旭,朱诗国,潘年松,等.黔产莪术油对直肠癌SW1463细胞株分泌Toll样受体及相关免疫因子的影响[J].中国实验方剂学杂志, 2018,24(5):137-141.
[20]	李玲玲,邵淑丽,孙宏岩,等.莪术油诱导人胃腺癌SGC-7901细胞凋亡的研究[J].中国细胞生物学学报,2015,37(9):1235-1241.
[21]	季宇彬,汲晨锋.黄芪多糖对肿瘤模型红细胞免疫功能的影响[J].现代食品科技,2013,29 (9):2042
[22]	盛耀光,刘少静,马休,等,黄芪多糖的药理作用及剂型研究进展[J],广州化工,2019,15(47):28-30
[23]	邹衡,丁磊,黎晶晶,等.黄芪甲苷抗肿瘤研究新进展[J].药物生物技术,2019,6(25):547-551
[24]	姚宝泰,赵健雄,王学习,等.黄芪总多糖体内抗肿瘤的实验研究[J].中华中医药杂志,2008,23(7):627-629.