医学营养治疗对妊娠期糖尿病患者胰岛素抵抗、瘦素水平及妊娠结局的影响

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Abstract Objective To study the effect of medical nutrition therapy on insulin resistance, leptin levels and pregnancy outcomes of patients with gestational diabetes mellitus.Methods One hundred patients with gestational diabetes mellitus who were put on file in our hospital between January 2018 and July 2019 were selected as the subjects. Sixty of these patients voluntarily received medical nutrition therapy and served as the study group, while the rest were subjected to general nutrition intervention and assigned to the control group. Insulin resistance, serum leptin levels and pregnancy outcomes were compared between the two groups.Results After twelve weeks of intervention, the fasting plasma glucose (4.81±0.47)mmol/L/(5.43±0.42)mmol/L, plasma glucose two hours after meal (6.49±0.54) mmol/L/(6.84±0.38)mmol/L, fasting insulin level (18.0±0.55) mIU/L/(18.41±0.39)mIU/L, glycohemoglobin (5.42±0.28)%/(5.83±0.26)%, insulin resistance index (3.91±0.16)/(4.24±0.27) and leptin level (17.99±0.61) ng/ml/(18.33±0.64)ng/ml in the study group were significantly lower than those of the control group (P＜0.01). The incidence of hypertensive disorder of pregnancy(6.67%), polyhydramnios(1.67%), macrosomia(8.33%) and fetal growth restriction(6.67%) in the study group was significantly lower than that of the control group (20.00%) (12.50%) (25.00%) (22.50%),(P＜0.05), so was the incidence of cesarean section(18.33%), postpartum hemorrhage(3.33%), fetal distress(6.67%), neonatal asphyxia(1.67%), neonatal respiratory distress syndrome(3.00%) and neonatal hypoglycemia(6.00%).Conclusions Medical nutrition therapy can effectively lower the levels of blood sugar and leptin in patients with gestational diabetes mellitus, improve insulin resistance, reduce maternal and infant complications, and prevent adverse pregnancy outcomes.

Key words： medical nutrition therapy gestational diabetes mellitus insulin resistance leptin pregnancy outcomes

Received: 20 April 2020

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R473. 71

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	WANG Jing
	DONG Xing
	WANG Jing
	SHANG Lixin

Cite this article:

WANG Jing,DONG Xing,WANG Jing等. Effect of medical nutrition therapy on insulin resistance, leptin level and pregnancy outcomes in patients with gestational diabetes mellitus[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(10): 881-884.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2020/V31/I10/881

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